| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
SP3 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
1-0, 5-1ug/ml, 5ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Optimal dilution of the SP3 antibody should be determined by the researcher |
| Intented use: |
This SP3 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q02447 |
| Purity: |
Antigen affinity |
| Description: |
A related pseudogene has been identified on chromosome 13, Additional isoforms, And this protein contains a zinc finger DNA-binding domain and several transactivation domains, This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes, Transcript variants encoding different isoforms have been described for this gene, also known as SP3, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes, and one has been reported to initiate translation from a non-AUG (AUA) start codon, have also been noted, refers to both a protein and the gene it is encoded by, resulting from the use of alternate downstream translation initiation sites, Sp3 transcription factor |
| Immunogen: |
Amino acids NTNDLTHLRVQVVDEEGDQQHQEGKRLRRVA of human SP3 were used as the immunogen for the SP3 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the SP3 antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
SP3 |
| Short name: |
SP3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Sp3 transcription factor (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0016605 and PML body and cellular component this GO :0017053 and transcriptional repressor complex and cellular component this GO :0030183 and B cell differentiation and biological process this GO :0030217 and T cell differentiation and biological process this GO :0030218 and erythrocyte differentiation and biological process this GO :0030219 and megakaryocyte differentiation and biological process this GO :0030224 and monocyte differentiation and biological process this GO :0030324 and lung development and biological process this GO :0030851 and granulocyte differentiation and biological process this GO :0043353 and enucleate erythrocyte differentiation and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048596 and embryonic camera-type eye morphogenesis and biological process this GO :0048706 and embryonic skeletal system development and biological process this GO :0060136 and embryonic process involved in female pregnancy and biological process this GO :0060216 and definitive hemopoiesis and biological process, SP3 and IDBG-640536 and ENSBTAG00000000176 and 540766, SP3 and IDBG-75293 and ENSG00000172845 and 6670, SPR2, Sp3 and IDBG-179756 and ENSMUSG00000027109 and 20687, metal ion binding, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000979 and RNA polymerase II core promoter sequence-specific DNA binding and molecular function this GO :0000987 and core promoter proximal region sequence-specific DNA binding and molecular function this GO :0001078 and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription and molecular function this GO :0001503 and ossification and biological process this GO :0001701 and in utero embryonic development and biological process this GO :0001779 and natural killer cell differentiation and biological process this GO :0001829 and trophectodermal cell differentiation and biological process this GO :0001889 and liver development and biological process this GO :0001892 and embryonic placenta development and biological process this GO :0003677 and DNA binding and molecular function this GO :0003682 and chromatin binding and molecular function this GO :0003690 and double-stranded DNA binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0006351 and transcription, this GO :0000979 : RNA polymerase II core promoter sequence-specific DNA binding, this GO :0000979 : RNA polymerase II core promoter sequence-specific DNA binding and also this GO :0000987 : core promoter proximal region sequence-specific DNA binding and also this GO :0001078 : RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription and also this GO :0003677 : DNA binding and also this GO :0003682 : chromatin binding and also this GO :0003690 : double-stranded DNA binding and also this GO :0005515 : protein binding and also this GO :0046872 : metal ion binding, this GO :0000987 : core promoter proximal region sequence-specific DNA binding, this GO :0001078 : RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription, this GO :0003677 : DNA binding, this GO :0003682 : chromatin binding, this GO :0003690 : double-stranded DNA binding, this GO :0005515 : protein binding, this GO :0046872 : metal ion binding, Sp3 transcription factor |
| Identity: |
11208 |
| Gene: |
SP3 |
More about : SP3 |
| Long gene name: |
Sp3 transcription factor |
| Synonyms: |
SPR-2 |
| Locus: |
2q31, 1 |
| Discovery year: |
1993-02-10 |
| GenBank acession: |
M97191 |
| Entrez gene record: |
6670 |
| Pubmed identfication: |
1341900 1454515 |
| RefSeq identity: |
NM_003111 |
| Classification: |
Sp transcription factors Zinc fingers C2H2-type |
| Havana BLAST/BLAT: |
OTTHUMG00000132333 |