| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Nociceptin receptor |
| Specificity: |
This antibody reacts specifically with Nociceptin receptor |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Extracellular |
| Antigen Source: |
KLH conjugated synthetic peptide derived from mouse Nociceptin receptor |
| Gene ID: |
18389 |
| Swiss Prot: |
P35377 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases, Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, Plays a role in modulating nociception and the perception of pain, Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin, Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity, G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
NOCIR ORL1 OOR KOR-3 NOPr |
| Also known as: |
Nociceptin receptor Polyclonal Antibody |
| Other name: |
Anti-Nociceptin receptor Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Description: |
2 or 3 and , However, In this sense, When such chemical-signals couple or bind to a receptor, a change in the electrical-activity of a cell, acetylcholine, am olfactory receptor is a protein-molecule that recognizes and responds to , an acetylcholine-receptor recognizes and responds to its endogenous-ligand, chemokinesor cytokines e, e, sometimes in pharmacology, such as enzymes, the term is also used to include other proteins that are drug-targets, they cause some form of cellular/tissue-response, transporters and ion-channels, The receptors are ligand binding factors of type 1, endogenous-chemical signals, g, g, protein-molecules , that receive chemical-signals from outside a cell |
| Gene target: |
Nociceptin receptor |
| Short name: |
Anti-Nociceptin receptor (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Nociceptin receptor (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
8155 |
| Gene: |
OPRL1 |
More about : OPRL1 |
| Long gene name: |
opioid related nociceptin receptor 1 |
| Synonyms gene name: |
opiate receptor-like 1 |
| Synonyms name: |
LC132 receptor-like orphanin FQ receptor kappa3-related opioid receptor nociceptin/orphanin FQ receptor |
| Locus: |
20q13, 33 |
| Discovery year: |
1996-05-28 |
| Entrez gene record: |
4987 |
| Pubmed identfication: |
8137918 17910740 |
| RefSeq identity: |
NM_182647 |
| Classification: |
Opioid receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000033027 |