| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
GTP cyclohydrolase 1 |
| Specificity: |
This antibody reacts specifically with GTP cyclohydrolase 1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human GTP-CH-1 |
| Gene ID: |
2643 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Animals can synthesize tetrahydrobiopterin in vivo from GTP through several enzymatic reactions, Tetrahydrobiopterin is an essential cofactor for 3 aromatic amino acid monooxygenases: phenylalanine, and tryptophan hydroxylases, the first and rate-limiting step in tetrahydrobiopterin (BH4) biosynthesis, tyrosine, 8-dihydroneopterin triphosphate, GTP cyclohydrolase I (also designated dopa-responsive dystonia) catalyzes the conversion of GTP to D-erythro-7 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
GTPCH1 DYT5a |
| Also known as: |
GTP cyclohydrolase 1 Polyclonal Antibody |
| Other name: |
Anti-GTP cyclohydrolase 1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
GTP cyclohydrolase 1 |
| Short name: |
Anti-GTP cyclohydrolase 1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-GTP cyclohydrolase 1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
4193 |
| Gene: |
GCH1 |
More about : GCH1 |
| Long gene name: |
GTP cyclohydrolase 1 |
| Synonyms gene: |
GCH DYT5 DYT14 |
| Synonyms gene name: |
dystonia 14 |
| Synonyms name: |
dopa-responsive dystonia |
| Locus: |
14q22, 2 |
| Discovery year: |
1988-05-11 |
| GenBank acession: |
U19523 |
| Entrez gene record: |
2643 |
| Pubmed identfication: |
7874165 8695054 |
| Havana BLAST/BLAT: |
OTTHUMG00000029754 |
| Locus Specific Databases: |
BIOMDBdb: Database of Mutations Causing BH4 Deficiencies and other PND |