| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
SERT / Serotonin Transporter / SLC6A4 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
1-0, 5ug/ml, Western blot: 0 |
| Notes: |
Optimal dilution of the Serotonin Transporter antibody should be determined by the researcher |
| Intented use: |
This Serotonin Transporter antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P31645 |
| Purity: |
Antigen affinity |
| Description: |
A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, It is a member of the sodium: neurotransmitter symporter family, The SLC6A4 gene spans 31 kb and contains 14 exons, This protein integral membrane protein transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons, This protein is the target of many antidepressant medications, This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it in a sodium-dependent manner, aggressive behavior in Alzheimer disease patients, also known as SERT (serotonin transporter), including those of the SSRI class, is a monoamine transporter protein, member 4), post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma, SLC6A4 (Solute carrier family 6 |
| Immunogen: |
Amino acids DDTRHSIPATTTTLVAELHQGERETWGKK of human SLC6A4 were used as the immunogen for the Serotonin Transporter antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the Serotonin Transporter antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Localization: |
Cell membrane |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
SERT / Serotonin Transporter / SLC6A4 |
| Short name: |
SERT Antibody / Serotonin Transporter / SLC6A4 |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
SERT (Antibody to) / Serotonin Transporter / SLC6A4 |
| Alternative technique: |
antibodies |
| Identity: |
11050 |
| Gene: |
SLC6A4 |
More about : SLC6A4 |
| Long gene name: |
solute carrier family 6 member 4 |
| Synonyms gene: |
HTT OCD1 |
| Synonyms gene name: |
member 4 , member 4 5-hydroxytryptamine (serotonin) transporter obsessive-compulsive disorder 1 solute carrier family 6 (neurotransmitter transporter), serotonin), solute carrier family 6 (neurotransmitter transporter |
| Synonyms: |
5-HTT SERT1 |
| Synonyms name: |
serotonin transporter 1 |
| Locus: |
17q11, 2 |
| Discovery year: |
1994-03-16 |
| GenBank acession: |
L05568 |
| Entrez gene record: |
6532 |
| Pubmed identfication: |
7681602 19806148 |
| RefSeq identity: |
NM_001045 |
| Classification: |
Solute carriers |
| Havana BLAST/BLAT: |
OTTHUMG00000132751 |