| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Caspase-10 |
| Specificity: |
This antibody reacts specifically with Caspase-10 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Secreted |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Caspase-10 |
| Gene ID: |
843 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
10b, 10c, 4, 6, 7, 8, 8, Caspase 10 (Mch4, Caspase 10 can cleave and activate caspases 3, Caspase 10 contains two death domains (DED) involved in linking to the death effector domain of the adapter protein FADD and recruiting the complex to TNFR1 and Fas, FLICE2) plays an important role in apoptosis induced by a variety of inducers such as TNF alpha and Anti-Fas antibody, Four isoforms of caspase 10 (caspase 10a, ICE-LAP4, Interestingly, It is a large prodomain caspase classified together with caspases 2, The inactive procaspase 10 is variably expressed in many tissues and cell lines as a cytosolic protein, The mature form of caspase 10 comprises two subunits, This is followed by cleavage of numerous key proteins, a caspase 9- dependent processing of caspase 10 by caspase 6 in cell-free extracts has recently been suggested, and 10d) having the same prodomain but different mature large and small subdomain, and 9, and 9 as a signaling caspase, have been described, including the nuclear protein PARP, p23/p17 (splice isoforms) and p12, Caspases are a family of intracellular proteases that mediate cell death and are the principal effectors of apoptosis |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
ALPS2, Apoptosis related cysteine peptidase, Apoptotic protease Mch 4, CASP 10, CASP10, CASP10 protein, Caspase 10 apoptosis related cysteine peptidase, Caspase 10 apoptosis related cysteine protease, Caspase10, FADD Like Ice 2, FAS associated death domain protein interleukin 1B converting enzyme 2, FLICE 2, FLICE2, Fas Associated Death Domain Protein, ICE Like Apoptotic Protease 4, Interleukin 1B Converting Enzyme 2, MCH 4, MCH4, ALPS 2 |
| Also known as: |
Caspase-10 Polyclonal Antibody |
| Other name: |
Anti-Caspase-10 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Caspase-10 |
| Short name: |
Anti-Caspase-10 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-caspase-10 (polyclonal) |
| Alternative technique: |
polyclonals |