| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
SPTLC1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
1-0, 5-1ug/ml, 5ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Optimal dilution of the SPTLC1 antibody should be determined by the researcher |
| Intented use: |
This SPTLC1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O15269 |
| Purity: |
Antigen affinity |
| Description: |
(2001) noted that the SPTLC1 gene maps to chromosome 9q22, Alternatively spliced variants encoding different isoforms have been identified, Dawkins et al, It converts L-serine and palmitoyl CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor, LCB1, Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1, Serine palmitoyltransferase, The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase, also known as SPT1, is a protein which in humans is encoded by the SPTLC1 gene, is the initial enzyme in sphingolipid biosynthesis, long chain base subunit 1), which consists of two different subunits, 1-q22, 3, SPTLC1 (Serine palmitoyltransferase |
| Immunogen: |
Amino acids IRVVVTVEQTEEELERAASTIKEVAQAVLL of human SPTLC1 were used as the immunogen for the SPTLC1 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the SPTLC1 antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term |
| Localization: |
Cytoplasmic |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
SPTLC1 |
| Short name: |
SPTLC1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
SPTLC1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11277 |
| Gene: |
SPTLC1 |
More about : SPTLC1 |
| Long gene name: |
serine palmitoyltransferase long chain base subunit 1 |
| Synonyms gene: |
HSN1 |
| Synonyms gene name: |
hereditary sensory neuropathy, type 1 |
| Synonyms: |
LCB1 SPTI HSAN1 hLCB1 |
| Locus: |
9q22, 31 |
| Discovery year: |
2000-07-31 |
| GenBank acession: |
Y08685 |
| Entrez gene record: |
10558 |
| Pubmed identfication: |
9363775 |
| RefSeq identity: |
NM_006415 |
| Havana BLAST/BLAT: |
OTTHUMG00000021047 |
| Locus Specific Databases: |
Inherited Peripheral Neuropathies Mutation Database LRG_272 |