| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
SPTLC1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the SPTLC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This SPTLC1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O15269 |
| Purity: |
Antigen affinity |
| Description: |
Alternatively spliced variants encoding different isoforms have been identified, Dawkins et al, It converts L-serine and palmitoyl CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor, LCB1, Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1, Serine palmitoyltransferase, The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase, also known as SPT1, is a protein which in humans is encoded by the SPTLC1 gene, is the initial enzyme in sphingolipid biosynthesis, long chain base subunit 1, which consists of two different subunits, (2001)noted that the gene maps to chromosome 9q22, 1-q22, 3, Serine palmitoyltransferase |
| Immunogen: |
An amino acid sequence from the middle region of human SPTLC1 (FYGTFDVHLDLEDRLAK) was used as the immunogen for this SPTLC1 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the SPTLC1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
SPTLC1 |
| Short name: |
SPTLC1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
SPTLC1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11277 |
| Gene: |
SPTLC1 |
More about : SPTLC1 |
| Long gene name: |
serine palmitoyltransferase long chain base subunit 1 |
| Synonyms gene: |
HSN1 |
| Synonyms gene name: |
hereditary sensory neuropathy, type 1 |
| Synonyms: |
LCB1 SPTI HSAN1 hLCB1 |
| Locus: |
9q22, 31 |
| Discovery year: |
2000-07-31 |
| GenBank acession: |
Y08685 |
| Entrez gene record: |
10558 |
| Pubmed identfication: |
9363775 |
| RefSeq identity: |
NM_006415 |
| Havana BLAST/BLAT: |
OTTHUMG00000021047 |
| Locus Specific Databases: |
Inherited Peripheral Neuropathies Mutation Database LRG_272 |