| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Menin |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the Menin antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This Menin antibodyis to be used only for research purposes and not for diagnostics |
| Gene ID #: |
4221 |
| Purity: |
Antigen affinity |
| Description: |
Additionally, In vitro studies have shown that the protein is localized to the nucleus, It has been found that that MEN1 inactivation by antisense RNA antagonizes transforming growth factor-beta-mediated cell growth inhibition, It is mapped to 11q13, MEN1 is considered to act as a tumor suppressor gene, MEN1 was essential to maintain MLL-associated myeloid transformation, Overexpression in an inducible cell culture system downregulated the proximal promoter, a nuclear scaffold protein that regulates gene transcription by coordinating chromatin remodeling, and inhibits transcriptional activation by JunD, possesses two functional nuclear localization signals, 1, The MEN1 gene encodes Menin |
| Immunogen: |
Human MEN1 shares 93% and 94% amino acid sequence identity with mouse and rat, respectively, Human partial recombinant protein (AA 301-615) was used as the immunogen for this Menin antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the Menin antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Menin |
| Short name: |
Menin Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Menin (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
7010 |
| Gene: |
MEN1 |
More about : MEN1 |
| Long gene name: |
menin 1 |
| Synonyms gene name: |
multiple endocrine neoplasia I |
| Synonyms name: |
menin |
| Locus: |
11q13 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
U93236 |
| Havana BLAST/BLAT: |
OTTHUMG00000045366 |
| Locus Specific Databases: |
UMD Locus Specific Databases LRG_509 |