| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
Hamartin |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the Hamartin antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This Hamartin antibodyis to be used only for research purposes and not for diagnostics |
| Gene ID #: |
7248 |
| Purity: |
Antigen affinity |
| Description: |
Hamartin and TSC2 have critical roles in neuronal polarity, It also can affect cell proliferation via deregulation of G1 phase, It forms a complex with TSC2 that regulates mTORC1 signaling and may be also involved in vesicular transport and docking, It is a growth inhibitory protein whose biologic effect is probably dependent on its interaction with tuberin, It is mapped to 9q34, Loss or perturbation of Hamartin function leads to loss of adhesion to the cellular matrix and initiates the development of TSC hamartomas, This peripheral membrane protein was implicated as a tumor suppressor, also known as Tuberous sclerosis 1, and that a common pathway regulates polarization and growth in neurons and cell size in other tissues, is a protein that in humans is encoded by the TSC1 gene, 13, Hamartin |
| Immunogen: |
Human partial recombinant protein (AA 686-884) was used as the immunogen for this Hamartin antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the Hamartin antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
Hamartin |
| Short name: |
Hamartin Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Hamartin (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
12362 |
| Gene: |
TSC1 |
More about : TSC1 |
| Long gene name: |
tuberous sclerosis 1 |
| Synonyms gene: |
TSC |
| Synonyms: |
KIAA0243 LAM hamartin |
| Locus: |
9q34 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
AF013168 |
| Pubmed identfication: |
9242607 10806479 |
| Havana BLAST/BLAT: |
OTTHUMG00000020844 |
| Locus Specific Databases: |
TSC Mutation Database Tuberous sclerosis database LRG_486 |