| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
ITGB4 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the ITGB4 antibody may be required due to differences in protocols and secondary/substrate sensitivity |
| Intented use: |
This ITGB4 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P16144 |
| Purity: |
Antigen affinity |
| Description: |
ITGB4 knockdown by short hairpin RNA countered ZKSCAN3-augmented anchorage-independent colony formation in the colon cancer cell lines, It tends to associate with alpha 6 subunits and is likely to play a pivotal role in the biology of invasive carcinoma, It was found that ITGB4 was upregulated 6-fold by ZKSCAN3 in transfected human colon cancer cells compared with parental cells and ZKSCAN3 has been confirmed as the promoter of ITGB4 in vitro and in vivo, also known as CD104, is a receptor for the laminin proteins, ITGB4 |
| Immunogen: |
Human partial recombinant protein (AA 28-266) was used as the immunogen for this ITGB4 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the ITGB4 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
ITGB4 |
| Short name: |
ITGB4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
b 4 (Antibody to), integrin |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CD104, Cell surfaces, ITGB4 and IDBG-643160 and ENSBTAG00000018169 and, ITGB4 and IDBG-68784 and ENSG00000132470 and 3691, Itgb4 and IDBG-214382 and ENSMUSG00000020758 and 192897, beta 4, protein binding, this GO :0001664 and G-protein coupled receptor binding and molecular function this GO :0004872 and receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005604 and basement membrane and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006914 and autophagy and biological process this GO :0007154 and cell communication and biological process this GO :0007155 and cell adhesion and biological process this GO :0007160 and cell-matrix adhesion and biological process this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0007275 and multicellular organismal development and biological process this GO :0008305 and integrin complex and cellular component this GO :0009611 and response to wounding and biological process this GO :0009925 and basal plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0030056 and hemidesmosome and cellular component this GO :0030198 and extracellular matrix organization and biological process this GO :0031252 and cell leading edge and cellular component this GO :0031581 and hemidesmosome assembly and biological process this GO :0034329 and cell junction assembly and biological process this GO :0043235 and receptor complex and cellular component this GO :0046847 and filopodium assembly and biological process this GO :0048870 and cell motility and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0001664 : G-protein coupled receptor binding, this GO :0001664 : G-protein coupled receptor binding and also this GO :0004872 : receptor activity and also this GO :0005515 : protein binding, this GO :0004872 : receptor activity, this GO :0005515 : protein binding, integrin |
| Identity: |
6158 |
| Gene: |
ITGB4 |
More about : ITGB4 |
| Long gene name: |
integrin subunit beta 4 |
| Synonyms gene name: |
beta 4 , integrin |
| Synonyms: |
CD104 |
| Locus: |
17q25, 1 |
| Discovery year: |
1991-08-06 |
| Entrez gene record: |
3691 |
| Pubmed identfication: |
2070796 |
| Classification: |
Integrin beta subunits CD molecules Fibronectin type III domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000179814 |