| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
PSD-95 (PSD95) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the PSD-95 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This PSD-95 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P78352 |
| Purity: |
Antigen affinity |
| Description: |
DLG2, DLG4 can heteromultimerize with another MAGUK protein, DLG4 can orchestrate synaptic development and it has a role in synapse stabilization and plasticity, It is a member of the membrane-associated guanylate kinase (MAGUK) family, Overexpression of DLG4 in hippocampal neurons could drive maturation of glutamatergic synapses, These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, Ubiquitination of DLG4 through an MDM2-mediated pathway can regulate AMPA receptor surface expression during synaptic plasticity, also known as Post-synaptic density protein 95 (PSD-95) or SAP-90, and associated signaling proteins, and is recruited into NMDA receptor and potassium channel clusters, ion channels, is a protein that in humans is encoded by the DLG4 gene, DLG4 (Discs large homolog 4) |
| Immunogen: |
mouse and rat), An amino acid sequence from the C-terminus of human PSD-95 (RRVERREWSRLKAKDW) was used as the immunogen for this PSD-95 antibody (100% homologous in human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the PSD-95 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
PSD (PSD95) |
| Short name: |
PSD-95 Antibody (PSD95) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
PSD-95 (Antibody to) (PSD95) |
| Alternative technique: |
antibodies |
| Identity: |
2903 |
| Gene: |
DLG4 |
More about : DLG4 |
| Long gene name: |
discs large MAGUK scaffold protein 4 |
| Synonyms gene name: |
discs, large homolog 4 (Drosophila) discs large homolog 4 |
| Synonyms: |
PSD-95 PSD95 SAP90 SAP-90 |
| Locus: |
17p13, 1 |
| Discovery year: |
1995-11-07 |
| GenBank acession: |
U83192 |
| Entrez gene record: |
1742 |
| Pubmed identfication: |
9286702 |
| RefSeq identity: |
NM_001365 |
| Classification: |
Membrane associated guanylate kinases PDZ domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000134327 |