| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
JAB1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the JAB1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This JAB1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q92905 |
| Purity: |
Antigen affinity |
| Description: |
COPS5/JAB1, In addition to that, It can interact with the cytoplasmic domain of the beta-2 subunit of the alpha-L/beta-2 integrin LFA1, It is a member of the MOV34 family, JAB1 is an essential cofactor for the apoptotic function of E2F1, The protein encoded by this gene is one of the eight subunits of COP9 signalosome, VHL, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways, also known as Jun activation domain binding protein 1 (JAB1), and TRC8 proteins appear to be linked both physically and functionally, and all three may participate in the development of kidney cancer, and it is the only protein demonstrated to interact with MIF, is a protein conserved from humans to Saccharomyces cerevisiae, COP9 constitutive photomorphogenic homolog subunit 5 (COPS5) |
| Immunogen: |
An amino acid sequence from the C-terminus of human Jun activation domain binding protein 1 (LMSQVIKDKLFNQINIS) was used as the immunogen for this JAB1 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the JAB1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
JAB1 |
| Short name: |
JAB1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
JAB1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2240 |
| Gene: |
COPS5 |
More about : COPS5 |
| Long gene name: |
COP9 signalosome subunit 5 |
| Synonyms gene name: |
Arabidopsis, COP9 (constitutive photomorphogenic, homolog) subunit 5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) |
| Synonyms: |
JAB1 SGN5 MOV-34 CSN5 |
| Locus: |
8q13, 1 |
| Discovery year: |
2000-06-08 |
| GenBank acession: |
U65928 |
| Entrez gene record: |
10987 |
| Pubmed identfication: |
8837781 9341143 |
| Classification: |
COP9 signalosome |
| Havana BLAST/BLAT: |
OTTHUMG00000164563 |