| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
BAG2 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the BAG2 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This BAG2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O95816 |
| Purity: |
Antigen affinity |
| Description: |
All three proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner, BAG2, The BAG domains of BAG1, The functional antagonisms displayed between BAG family proteins and Hip suggest that a proper balance of these two types of protein is required for achieving optimal cycles of substrate binding and release required for inducting conformational changes in proteins, The predicted protein contains 211 amino acids, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells, with Hip promoting peptide substrate binding by Hsc70/Hsp70 and BAG family proteins promoting dissociation, BAG family molecular chaperone regulator 2 is a protein that in humans is encoded by the BAG2 gene |
| Immunogen: |
An amino acid sequence from the N-terminus of human BAG family molecular chaperone regulator 2 (MAQAKINAKANEGR) was used as the immunogen for this BAG2 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the BAG2 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
BAG2 |
| Short name: |
BAG2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
B-cell CLL/lymphoma 2-associated athanogene 2 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BAG-2 and dJ417I1, BAG2 and IDBG-628617 and ENSBTAG00000005355 and 506107, BAG2 and IDBG-91571 and ENSG00000112208 and 9532, Bag2 and IDBG-140714 and ENSMUSG00000042215 and 213539, chaperone binding, multiple, this GO :0005515 and protein binding and molecular function this GO :0006457 and protein folding and biological process this GO :0019538 and protein metabolic process and biological process this GO :0051087 and chaperone binding and molecular function, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0051087 : chaperone binding, this GO :0051087 : chaperone binding, 2, BCL2-associated athanogene 2 |
| Identity: |
938 |
| Gene: |
BAG2 |
More about : BAG2 |
| Long gene name: |
BCL2 associated athanogene 2 |
| Locus: |
6p12, 1 |
| Discovery year: |
1999-04-23 |
| GenBank acession: |
AF095192 |
| Entrez gene record: |
9532 |
| Pubmed identfication: |
9873016 |
| Classification: |
BCL2 associated athanogene family |
| Havana BLAST/BLAT: |
OTTHUMG00000014919 |