| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
CXCR1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the CXCR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This CXCR1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P25024 |
| Purity: |
Antigen affinity |
| Description: |
Binding of IL-8 to its receptor causes activation of neutrophils, CXCR1 binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity, Hartl et al, Morris et al, This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system, also known as IL8R, is the receptor for IL8, (1992) mapped the gene to chromosome 2q35, (2007) concluded that CXCR1 cleavage and its functional consequences represent an important pathophysiologic mechanism in CF and other neutrophilic airway diseases, Chemokine CXC Motif Receptor 1 |
| Immunogen: |
An amino acid sequence from the N-terminus of human Chemokine CXC Motif Receptor 1 (DEDYSPCMLETETLN) was used as the immunogen for this CXCR1 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the CXCR1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
CXCR1 |
| Short name: |
CXCR1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
chemokine (C-X-C motif) receptor 1 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
C-C and C-C-CKR-1 and CD128 and CD181 and CDw128a and CKR-1 and CMKAR1 and IL8R1 and IL8RA and IL8RBA, CXCR1 and IDBG-80821 and ENSG00000163464 and 3577, Cxcr1 and IDBG-166431 and ENSMUSG00000048480 and 227288, Plasma membranes, interleukin-8 binding, this GO :0002407 and dendritic cell chemotaxis and biological process this GO :0004918 and interleukin-8 receptor activity and molecular function this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0004950 and chemokine receptor activity and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0006935 and chemotaxis and biological process this GO :0006954 and inflammatory response and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0019959 and interleukin-8 binding and molecular function this GO :0031623 and receptor internalization and biological process this GO :0038112 and interleukin-8-mediated signaling pathway and biological process this GO :0070098 and chemokine-mediated signaling pathway and biological process, this GO :0004918 : interleukin-8 receptor activity, this GO :0004918 : interleukin-8 receptor activity and also this GO :0004930 : G-protein coupled receptor activity and also this GO :0004950 : chemokine receptor activity and also this GO :0019959 : interleukin-8 binding, this GO :0004930 : G-protein coupled receptor activity, this GO :0004950 : chemokine receptor activity, this GO :0019959 : interleukin-8 binding, chemokine (C-X-C motif) receptor 1 |
| Identity: |
6026 |
| Gene: |
CXCR1 |
More about : CXCR1 |
| Long gene name: |
C-X-C motif chemokine receptor 1 |
| Synonyms gene: |
CMKAR1 IL8RA |
| Synonyms gene name: |
alpha chemokine (C-X-C motif) receptor 1 , interleukin 8 receptor |
| Synonyms: |
CKR-1 CDw128a CD181 |
| Locus: |
2q35 |
| Discovery year: |
1992-11-09 |
| GenBank acession: |
U11870 |
| Entrez gene record: |
3577 |
| Pubmed identfication: |
1303245 1427896 |
| RefSeq identity: |
NM_000634 |
| Classification: |
CD molecules C-X-C motif chemokine receptors Interleukin receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000133108 |