| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
p53R2 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the p53R2 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This p53R2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q7LG56 |
| Purity: |
Antigen affinity |
| Description: |
DNA repair, Induction of p53R2 in p53-deficient cells caused G2/M arrest and protected cells from death in response to adriamycin, Inhibition of endogenous p53R2 expression in cells that had an intact p53-dependent DNA damage checkpoint reduced ribonucleotide reductase activity, M2 B, Tanaka et al, Tanaka et al, also known as P53R2, and cell survival after exposure to various genotoxins, but not R2, is an enzyme that in humans is encoded by the RRM2B gene, was induced by ultraviolet and gamma-irradiation and adriamycin treatment in a wildtype p53-dependent manner, (2000) found that expression of p53R2, (2000) mapped the gene to chromosome 8q23, 1 by fluorescence in situ hybridization, Ribonucleotide Reductase |
| Immunogen: |
mouse and rat), An amino acid sequence from the C-terminus of human p53 reductase small subunit 2 (EGKTNFFEKRVSEYQ) was used as the immunogen for this p53R2 antibody (100% homologous in human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the p53R2 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
p53R2 |
| Short name: |
p53R2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
p53R2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
17296 |
| Gene: |
RRM2B |
More about : RRM2B |
| Long gene name: |
ribonucleotide reductase regulatory TP53 inducible subunit M2B |
| Synonyms gene name: |
ribonucleotide reductase M2 B (TP53 inducible) |
| Synonyms: |
p53R2 |
| Locus: |
8q22, 3 |
| Discovery year: |
2002-01-14 |
| GenBank acession: |
AB036532 |
| Entrez gene record: |
50484 |
| Pubmed identfication: |
10716435 10980602 17486094 |
| Havana BLAST/BLAT: |
OTTHUMG00000164776 |
| Locus Specific Databases: |
LRG_788 |