| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
DR3 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the DR3 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This DR3 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q93038 |
| Purity: |
Antigen affinity |
| Description: |
APO3, By fluorescence in situ hybridization, DR3 may regulate distinct signaling pathways in different cellular contexts, DR3 or TNFR25, Marsters et al, Marsters et al, Members of the mammalian tumor necrosis factor receptor(TNFR) family are cell-surface proteins that interact with a corresponding TNF-related ligand family, They suggested that, also known as LARD, is a protein that in humans is encoded by the TNFRSF25 gene, like TNFR1, (1996) mapped the gene to 1p36, (1996) showed that ectopic expression of DR3 in mammalian cells triggered apoptosis and activated the transcription factor NF-kappa-B, 3, TNFRSF25 (Tumor Necrosis Factor Receptor Superfamily Member 25) |
| Immunogen: |
An amino acid sequence from the N-terminus of human Death receptor 3 (CPQDTFLAWENHHNSECARCQA) was used as the immunogen for this DR3 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the DR3 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
DR3 |
| Short name: |
DR3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
DR3 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11910 |
| Gene: |
TNFRSF25 |
More about : TNFRSF25 |
| Long gene name: |
TNF receptor superfamily member 25 |
| Synonyms gene: |
TNFRSF12 |
| Synonyms gene name: |
member 12 (translocating chain-association membrane protein) tumor necrosis factor receptor superfamily, member 25 , tumor necrosis factor receptor superfamily |
| Synonyms: |
DR3 TRAMP WSL-1 LARD WSL-LR DDR3 TR3 APO-3 |
| Locus: |
1p36, 31 |
| Discovery year: |
1998-12-04 |
| GenBank acession: |
U72763 |
| Entrez gene record: |
8718 |
| Pubmed identfication: |
9052839 8934525 |
| RefSeq identity: |
NM_148965 |
| Classification: |
Tumor necrosis factor receptor superfamily |
| Havana BLAST/BLAT: |
OTTHUMG00000000831 |