| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
TrkC |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the TrkC antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This TrkC antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q16288 |
| Purity: |
Antigen affinity |
| Description: |
By PCR analysis of a somatic cell hybrid panel and by fluorescence in situ hybridization with the cDNA clone, By functional studies in HeLa cells, Lamballe et al, McGregor et al, Muinos-Gimeno et al, Signaling through TrkC leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position, The protein is a heavily glycosylated molecule with 13 potential N-linked glycosylation sites within the extracellular domain, They found that TRKC is preferentially expressed in the brain, a member of the TRK family of tyrosine protein kinase genes, also known as TRKC, and the granular cell layer of the cerebellum, cerebral cortex, in situ hybridization studies showed transcripts in the hippocampus, is a protein that in humans is encoded by the NTRK3 gene, (1991) isolated and characterized TRKC, (1994) mapped the NTRK3 gene to 15q24-q25, (2009) demonstrated that 5 miRNAs regulate the truncated form of NTRK3, NTRK3(Neurotrophic Tyrosine Kinase Receptor Type 3) |
| Immunogen: |
An amino acid sequence from the N-terminus of human TrkC (QLWQEQGEAKLNSQN) was used as the immunogen for this TrkC antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the TrkC antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
TrkC |
| Short name: |
TrkC Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TrkC (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8033 |
| Gene: |
NTRK3 |
More about : NTRK3 |
| Long gene name: |
neurotrophic receptor tyrosine kinase 3 |
| Synonyms gene name: |
neurotrophic tyrosine kinase, receptor, type 3 |
| Synonyms: |
TRKC |
| Locus: |
15q25, 3 |
| Discovery year: |
1991-07-18 |
| GenBank acession: |
U05012 |
| Entrez gene record: |
4916 |
| Pubmed identfication: |
7806211 |
| Classification: |
I-set domain containing Receptor Tyrosine Kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000148677 |