| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
VDR (Vitamin D Receptor) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the VDR antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This VDR antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P11473 |
| Purity: |
Antigen affinity |
| Description: |
A natural polymorphic variant of the receptor, Conversely, Jurutka et al, Labuda et al, Shah et al, Using mutation analysis, VDR residues immediately N-terminal of the first DNA-binding zinc finger, also known as Vitamin D Hormone Receptor, as vital for contact with the general transcription factor IIB(TFIIB), high levels of beta-catenin can potentiate the transcriptional activity of 1, interacted more efficiently with TFIIB and also possessed elevated transcriptional activity compared with the full-length(f/M1) receptor, is a member of the nuclear receptor family of transcription factors, termed F/M4(missing a FokI restriction site), which lacks only the first 3 amino acids(including glu2), (1991) assigned the VDR gene to 12q12-q14 by in situ hybridization, (2000) characterized arg18/arg22, (2006) stated that the signaling and oncogenic activity of beta-catenin(CTNNB1) can be repressed by activation of VDR, 25-dihydroxyvitamin D3, Vitamin D Receptor |
| Immunogen: |
An amino acid sequence from the C-terminus of human Vitamin D Receptor (DLRSLNEEHSKQYRCL) was used as the immunogen for this VDR antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the VDR antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
VDR (Vitamin D Receptor) |
| Short name: |
VDR Antibody (Vitamin D Receptor) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
25- dihydroxyvitamin D3) receptor (Antibody to) (Vitamin D Receptor), vitamin D (1 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006367 and transcription initiation from RNA polymerase II promoter and biological process this GO :0006816 and calcium ion transport and biological process this GO :0006874 and cellular calcium ion homeostasis and biological process this GO :0007165 and signal transduction and biological process this GO :0007275 and multicellular organismal development and biological process this GO :0007595 and lactation and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008434 and vitamin D3 receptor activity and molecular function this GO :0009887 and organ morphogenesis and biological process this GO :0010467 and gene expression and biological process this GO :0010628 and positive regulation of gene expression and biological process this GO :0010839 and negative regulation of keratinocyte proliferation and biological process this GO :0010980 and positive regulation of vitamin D 24-hydroxylase activity and biological process this GO :0038183 and bile acid signaling pathway and biological process this GO :0038186 and lithocholic acid receptor activity and molecular function this GO :0043401 and steroid hormone mediated signaling pathway and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045618 and positive regulation of keratinocyte differentiation and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046697 and decidualization and biological process this GO :0046965 and retinoid X receptor binding and molecular function this GO :0050892 and intestinal absorption and biological process this GO :0060058 and positive regulation of apoptotic process involved in mammary gland involution and biological process this GO :0060558 and regulation of calcidiol 1-monooxygenase activity and biological process this GO :0060745 and mammary gland branching involved in pregnancy and biological process this GO :0070561 and vitamin D receptor signaling pathway and biological process this GO :0070644 and vitamin D response element binding and molecular function this GO :1902098 and calcitriol binding and molecular function this GO :1902121 and lithocholic acid binding and molecular function, NR1I1 and PPP1R163, VDR and IDBG-29237 and ENSG00000111424 and 7421, VDR and IDBG-633008 and ENSBTAG00000016414 and 533656, Vdr and IDBG-179227 and ENSMUSG00000022479 and 22337, lithocholic acid binding, nuclei, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000902 and cell morphogenesis and biological process this GO :0001501 and skeletal system development and biological process this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0003707 and steroid hormone receptor activity and molecular function this GO :0004879 and ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0006351 and transcription, this GO :0003677 : DNA binding, this GO :0003677 : DNA binding and also this GO :0003700 : sequence-specific DNA binding transcription factor activity and also this GO :0003707 : steroid hormone receptor activity and also this GO :0004879 : ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity and also this GO :0005515 : protein binding and also this GO :0008270 : zinc ion binding and also this GO :0008434 : vitamin D3 receptor activity and also this GO :0038186 : lithocholic acid receptor activity and also this GO :0043565 : sequence-specific DNA binding and also this GO :0046965 : retinoid X receptor binding and also this GO :0070644 : vitamin D response element binding and also this GO :1902098 : calcitriol binding and also this GO :1902121 : lithocholic acid binding, this GO :0003700 : sequence-specific DNA binding transcription factor activity, this GO :0003707 : steroid hormone receptor activity, this GO :0004879 : ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, this GO :0005515 : protein binding, this GO :0008270 : zinc ion binding, this GO :0008434 : vitamin D3 receptor activity, this GO :0038186 : lithocholic acid receptor activity, this GO :0043565 : sequence-specific DNA binding, this GO :0046965 : retinoid X receptor binding, this GO :0070644 : vitamin D response element binding, this GO :1902098 : calcitriol binding, this GO :1902121 : lithocholic acid binding, 25- dihydroxyvitamin D3) receptor, vitamin D (1 |
| Identity: |
12679 |
| Gene: |
VDR |
More about : VDR |
| Long gene name: |
vitamin D (1, 25- dihydroxyvitamin D3) receptor |
| Synonyms: |
NR1I1 PPP1R163 |
| Synonyms name: |
protein phosphatase 1, regulatory subunit 163 |
| Locus: |
12q13, 11 |
| Discovery year: |
1989-06-30 |
| GenBank acession: |
J03258 |
| Entrez gene record: |
7421 |
| Pubmed identfication: |
1662663 |
| Classification: |
Nuclear hormone receptors Protein phosphatase 1 regulatory subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000169890 |
| Locus Specific Databases: |
ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database |