| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
PTCH2 (Patched 2) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the PTCH2 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This PTCH2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
Q9Y6C5 |
| Purity: |
Antigen affinity |
| Description: |
Mutations in the human Patched gene are the basis of the nevoid basal cell carcinoma syndrome, The Patched-hedgehog signaling pathway is involved in establishing segment polarity and the anterior-posterior orientation of a number of developing appendages, The pathway is conserved from fly to vertebrates and has been implicated in a number of human neoplasms and developmental syndromes, With age, also known as PTC2, encodes a 1, homozygous mutant male mice developed skin lesions consisting of alopecia and epidermal hyperplasia, suggesting a role for PTCH2 in adult epidermal homeostasis via Shh signaling, 203-amino acid putative transmembrane protein that is highly homologous to the PTCH product, PTCH2 (Patched 2) |
| Immunogen: |
An amino acid sequence from the C-terminus of human Patched 2 (WLHDKYDTTGENLRIPP) was used as the immunogen for this PTCH2 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the PTCH2 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
PTCH2 (Patched 2) |
| Short name: |
PTCH2 Antibody (Patched 2) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
PTCH2 (Antibody to) (Patched 2) |
| Alternative technique: |
antibodies |
| Identity: |
9586 |
| Gene: |
PTCH2 |
More about : PTCH2 |
| Long gene name: |
patched 2 |
| Synonyms gene name: |
patched (Drosophila) homolog 2 patched homolog 2 (Drosophila) |
| Locus: |
1p34, 1 |
| Discovery year: |
1998-10-19 |
| GenBank acession: |
AF091501 |
| Entrez gene record: |
8643 |
| Pubmed identfication: |
9811851 9931336 |
| RefSeq identity: |
NM_003738 |
| Havana BLAST/BLAT: |
OTTHUMG00000008490 |