| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
LOX-1 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the LOX-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This LOX-1 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P78380 |
| Purity: |
Antigen affinity |
| Description: |
Incubation of the cells with LDL had no effect on OLR1/LOX-1 expression, LOX-1 is expressed in macrophages, The OLR1 gene encodes a cell-surface endocytosis receptor for oxidized low density lipoprotein (OxLDL), The OLR1 gene is mapped on 12p13, also called CLEC8A and LOX-1 (Lectin type oxidized LDL receptor 1), but incubation with OxLDL resulted in a dose-dependent increase in mRNA and protein expression, but not in vascular smooth muscle cells, is a receptor which belongs to the C-type lectin superfamily, suggesting a role for the receptor in the pathophysiology of atherosclerotic cardiovascular disease, 2, OLR1 (oxidized low density lipoprotein(lectin-like) receptor 1) |
| Immunogen: |
An amino acid sequence from the middle region of human LOX-1/OLR1 (NEKSKEQMELHHQN) was used as the immunogen for this LOX-1 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the LOX-1 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
LOX-1 |
| Short name: |
LOX-1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
LOX-1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8133 |
| Gene: |
OLR1 |
More about : OLR1 |
| Long gene name: |
oxidized low density lipoprotein receptor 1 |
| Synonyms gene name: |
oxidised low density lipoprotein (lectin-like) receptor 1 |
| Synonyms: |
LOX-1 SCARE1 CLEC8A |
| Locus: |
12p13, 2 |
| Discovery year: |
1998-01-16 |
| GenBank acession: |
D89050 |
| Entrez gene record: |
4973 |
| Pubmed identfication: |
9763655 |
| RefSeq identity: |
NM_002543 |
| Classification: |
Scavenger receptors C-type lectin domain family |
| Havana BLAST/BLAT: |
OTTHUMG00000168527 |