| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
SHIP2 (INPPL1) |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the SHIP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This SHIP2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
O15357 |
| Purity: |
Antigen affinity |
| Description: |
Immunoblot analysis revealed that the protein is widely expressed in fibroblast and nonhematopoietic tumor cell lines, SHIP2 is a member of the family of inositol triphosphate phosphatases, The protein may play a significant role in regulation of phosphatidylinositol 3-prime-kinase signaling by growth factors and insulin, Using human epithelial cell lines and primary human corneal and epidermal keratinocytes, Yu et al, also called SHIP2, encodes a protein that in addition to the phosphatase domain contains an SH2 (src-homology domain 2) motif, unlike the SHIP1 protein, which was found only in cell lines of hematopoietic origin, (2008) showed that microRNA-184(MIR184) interfered with the ability of MIR205 to downregulate expression of SHIP2, Inositol polyphosphate phosphatase-like 1 |
| Immunogen: |
mouse and rat), An amino acid sequence from the middle region of human SHIP2/INPPL1 (QRDSQEDWTTFTHDR) was used as the immunogen for this SHIP2 antibody (100% homologous in human |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the SHIP2 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
SHIP2 (INPPL1) |
| Short name: |
SHIP2 Antibody (INPPL1) |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
SHIP2 (Antibody to) (inositol polyphosphate phosphatase-like 1) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
INPPL1 and IDBG-63291 and ENSG00000165458 and 3636, INPPL1 and IDBG-635082 and ENSBTAG00000019167 and 783833, Inppl1 and IDBG-202184 and ENSMUSG00000032737 and 16332, OPSMD and SHIP2, Plasma membranes, SH2 domain binding, this GO :0001958 and endochondral ossification and biological process this GO :0002376 and immune system process and biological process this GO :0003779 and actin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005829 and cytosol and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006006 and glucose metabolic process and biological process this GO :0006644 and phospholipid metabolic process and biological process this GO :0006661 and phosphatidylinositol biosynthetic process and biological process this GO :0006897 and endocytosis and biological process this GO :0007015 and actin filament organization and biological process this GO :0007155 and cell adhesion and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0009791 and post-embryonic development and biological process this GO :0010629 and negative regulation of gene expression and biological process this GO :0016787 and hydrolase activity and molecular function this GO :0017124 and SH3 domain binding and molecular function this GO :0030027 and lamellipodium and cellular component this GO :0030175 and filopodium and cellular component this GO :0032868 and response to insulin and biological process this GO :0042169 and SH2 domain binding and molecular function this GO :0043647 and inositol phosphate metabolic process and biological process this GO :0044255 and cellular lipid metabolic process and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0046856 and phosphatidylinositol dephosphorylation and biological process this GO :0097178 and ruffle assembly and biological process, this GO :0003779 : actin binding, this GO :0003779 : actin binding and also this GO :0005515 : protein binding and also this GO :0016787 : hydrolase activity and also this GO :0017124 : SH3 domain binding and also this GO :0042169 : SH2 domain binding, this GO :0005515 : protein binding, this GO :0016787 : hydrolase activity, this GO :0017124 : SH3 domain binding, this GO :0042169 : SH2 domain binding, inositol polyphosphate phosphatase-like 1 |
| Identity: |
6080 |
| Gene: |
INPPL1 |
More about : INPPL1 |
| Long gene name: |
inositol polyphosphate phosphatase like 1 |
| Synonyms: |
SHIP2 |
| Synonyms name: |
51C protein SH2 domain-containing inositol 5', -phosphatase 2 phosphatidylinositol 3, 4, 5-trisphosphate 5-phosphatase 2 |
| Locus: |
11q13, 4 |
| Discovery year: |
1995-05-12 |
| GenBank acession: |
Y14385 |
| Entrez gene record: |
3636 |
| Pubmed identfication: |
8530088 |
| RefSeq identity: |
NM_001567 |
| Classification: |
Phosphoinositide phosphatases Sterile alpha motif domain containing SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000167879 |