| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
INPPL1 |
| Specificity: |
This antibody reacts specifically with INPPL1 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cell membrane, Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human INPPL1 |
| Gene ID: |
3636 |
| Swiss Prot: |
O15357 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation, Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A), Acts as a regulator of neuritogenesis by regulating PtdIns(3, Confers resistance to dietary obesity, Involved in EGF signaling pathway, May act by regulating AKT2, Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), Part of a signaling pathway that regulates actin cytoskeleton remodeling, Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3, Plays a central role in regulation of PI3K-dependent insulin signaling, Plays a negative role in regulating the PI3K-PKB pathway, Regulates cell adhesion and cell spreading, Required for HGF-mediated lamellipodium formation, Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, Upon stimulation by EGF, While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, although the precise molecular mechanisms and signaling pathways remain unclear, and later, but not AKT1, cell scattering and spreading, having a major impact on ligand-induced EGFR internalization and degradation, it is recruited by EGFR and dephosphorylates PtdIns(3, its absence does not affect insulin signaling or GLUT4 trafficking, maintain proper neurite outgrowth, phosphorylation at the plasma membrane, playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems, possibly by inhibiting PKB activity, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways, 4, 4, 4, 4, 4, 4)P2, 5)P3, 5)P3 level and is required to form an initial protrusive pattern, 5)P3 thereby regulating membrane ruffling, 5)P3) to produce PtdIns(3, 5-trisphosphate (PtdIns(3, Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3 |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
SHIP2 |
| Also known as: |
INPPL1 Polyclonal Antibody |
| Other name: |
Anti-INPPL1 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
INPPL1 |
| Short name: |
Anti-INPPL1 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-inositol polyphosphate phosphatase-like 1 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
INPPL1 and IDBG-63291 and ENSG00000165458 and 3636, INPPL1 and IDBG-635082 and ENSBTAG00000019167 and 783833, Inppl1 and IDBG-202184 and ENSMUSG00000032737 and 16332, OPSMD and SHIP2, Plasma membranes, SH2 domain binding, this GO :0001958 and endochondral ossification and biological process this GO :0002376 and immune system process and biological process this GO :0003779 and actin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005829 and cytosol and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006006 and glucose metabolic process and biological process this GO :0006644 and phospholipid metabolic process and biological process this GO :0006661 and phosphatidylinositol biosynthetic process and biological process this GO :0006897 and endocytosis and biological process this GO :0007015 and actin filament organization and biological process this GO :0007155 and cell adhesion and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0009791 and post-embryonic development and biological process this GO :0010629 and negative regulation of gene expression and biological process this GO :0016787 and hydrolase activity and molecular function this GO :0017124 and SH3 domain binding and molecular function this GO :0030027 and lamellipodium and cellular component this GO :0030175 and filopodium and cellular component this GO :0032868 and response to insulin and biological process this GO :0042169 and SH2 domain binding and molecular function this GO :0043647 and inositol phosphate metabolic process and biological process this GO :0044255 and cellular lipid metabolic process and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0046856 and phosphatidylinositol dephosphorylation and biological process this GO :0097178 and ruffle assembly and biological process, this GO :0003779 : actin binding, this GO :0003779 : actin binding and also this GO :0005515 : protein binding and also this GO :0016787 : hydrolase activity and also this GO :0017124 : SH3 domain binding and also this GO :0042169 : SH2 domain binding, this GO :0005515 : protein binding, this GO :0016787 : hydrolase activity, this GO :0017124 : SH3 domain binding, this GO :0042169 : SH2 domain binding, inositol polyphosphate phosphatase-like 1 |
| Identity: |
6080 |
| Gene: |
INPPL1 |
More about : INPPL1 |
| Long gene name: |
inositol polyphosphate phosphatase like 1 |
| Synonyms name: |
51C protein SH2 domain-containing inositol 5', -phosphatase 2 phosphatidylinositol 3, 4, 5-trisphosphate 5-phosphatase 2 |
| Locus: |
11q13, 4 |
| Discovery year: |
1995-05-12 |
| GenBank acession: |
Y14385 |
| Entrez gene record: |
3636 |
| Pubmed identfication: |
8530088 |
| RefSeq identity: |
NM_001567 |
| Classification: |
Phosphoinositide phosphatases Sterile alpha motif domain containing SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000167879 |