| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
IL4R |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the IL4R antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This IL4R antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P24394 |
| Purity: |
Antigen affinity |
| Description: |
IL4 interacts with IL4R with high affinity, IL4 plays a major role in immunoglobulin E(IgE) production, Its signal is conferred to effector cells through binding to the alpha chain of the IL4 receptor, The IL4R gene contains 12 exons and the protein is a complex of at least two components, The gene is localized to 16p12, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells, leading to dimerization with either the common gamma chain, one of which is a novel affinity converting subunit that is critical for cellular signal transduction, or with IL13RA1 to form a type II receptor, to create a type I receptor, 1-p11, 2 by in situ hybridization and Southern blot analysis of DNA from a panel of mouse-human somatic cell lines, IL4R (Interleukin 4 receptor) is a human gene that encodes the alpha chain of the interleukin-4 receptor, a component of receptors for a number of cytokines |
| Immunogen: |
An amino acid sequence from the middle region of human IL4R (TKWHNSYREPFEQH) was used as the immunogen for this IL4R antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the IL4R antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
IL4R |
| Short name: |
IL4R Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
interleukin 4 receptor (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CD124 and IL-4RA and IL4RA, Extracellular, IL4R and IDBG-21808 and ENSG00000077238 and 3566, IL4R and IDBG-638778 and ENSBTAG00000001602 and 404154, Il4ra and IDBG-209275 and ENSMUSG00000030748 and 16190, insulin receptor substrate binding, this GO :0002532 and production of molecular mediator involved in inflammatory response and biological process this GO :0004896 and cytokine receptor activity and molecular function this GO :0004913 and interleukin-4 receptor activity and molecular function this GO :0005057 and receptor signaling protein activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006955 and immune response and biological process this GO :0007165 and signal transduction and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0030728 and ovulation and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0035771 and interleukin-4-mediated signaling pathway and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042832 and defense response to protozoan and biological process this GO :0043032 and positive regulation of macrophage activation and biological process this GO :0043235 and receptor complex and cellular component this GO :0043560 and insulin receptor substrate binding and molecular function this GO :0043627 and response to estrogen and biological process this GO :0045087 and innate immune response and biological process this GO :0045626 and negative regulation of T-helper 1 cell differentiation and biological process this GO :0045630 and positive regulation of T-helper 2 cell differentiation and biological process this GO :0090197 and positive regulation of chemokine secretion and biological process, this GO :0004896 : cytokine receptor activity, this GO :0004896 : cytokine receptor activity and also this GO :0004913 : interleukin-4 receptor activity and also this GO :0005057 : receptor signaling protein activity and also this GO :0005515 : protein binding and also this GO :0043560 : insulin receptor substrate binding, this GO :0004913 : interleukin-4 receptor activity, this GO :0005057 : receptor signaling protein activity, this GO :0005515 : protein binding, this GO :0043560 : insulin receptor substrate binding, interleukin 4 receptor |
| Identity: |
6015 |
| Gene: |
IL4R |
More about : IL4R |
| Long gene name: |
interleukin 4 receptor |
| Synonyms: |
CD124 |
| Synonyms name: |
interleukin 13 receptor |
| Locus: |
16p12, 1 |
| Discovery year: |
1990-07-06 |
| GenBank acession: |
X52425 |
| Entrez gene record: |
3566 |
| Pubmed identfication: |
1679753 |
| Classification: |
CD molecules Interleukin receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000097015 |