| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
CCR10 |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the CCR10 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This CCR10 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P46092 |
| Purity: |
Antigen affinity |
| Description: |
By fluorescence in situ hybridization, CCR10 is the receptor for CCL27, CCR10+ T lymphocytes were detected in lesional but not normal skin of these patients, CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation, Expression was also detected in T cells, Flow cytometric analysis showed that CCL27 binds extracellular matrix components and dermal microvascular endothelial cells and fibroblasts and mediates adhesion and transendothelial migration of CCR10+ circulating leukocytes, It is constitutively expressed in skin melanocytes, Langerhans cells, RT-PCR, The protein is predominantly expressed on CD4+CLA+(cutaneous lymphocyte antigen), and ELISA analysis indicated that keratinocytes exposed to TNF or IL1B but not to IL4 or IFNG in vitro express increased CCL27, and microvascular endothelial cells, and peripheral blood mononuclear cells but not in dendritic cells, and psoriasis patients, and that it is upregulated by IL1B and TNF, circulating T cells, confocal microscopy, contact dermatitis, expression of CCL27 in normal keratinocytes and its strong upregulation in skin lesions of atopic dermatitis, fibroblasts, rather than CD8+, the gene is mapped to 17q21, 1-q21, 3, C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10 gene |
| Immunogen: |
Amino acids 312-327 (FLGLRFRQDLRRLLRG-human) were used as the immunogen for this CCR10 antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the CCR10 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
CCR10 |
| Short name: |
CCR10 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
chemokine (C-C motif) receptor 10 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
C-C chemokine receptor activity, CCR10 and IDBG-51414 and ENSG00000184451 and 2826, CCR10 and IDBG-640334 and ENSBTAG00000019095 and 539108, Ccr10 and IDBG-211910 and ENSMUSG00000044052 and 12777, GPR2, Plasma membranes, this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0004950 and chemokine receptor activity and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006935 and chemotaxis and biological process this GO :0006955 and immune response and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007204 and positive regulation of cytosolic calcium ion concentration and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0016493 and C-C chemokine receptor activity and molecular function, this GO :0004930 : G-protein coupled receptor activity, this GO :0004930 : G-protein coupled receptor activity and also this GO :0004950 : chemokine receptor activity and also this GO :0016493 : C-C chemokine receptor activity, this GO :0004950 : chemokine receptor activity, this GO :0016493 : C-C chemokine receptor activity, chemokine (C-C motif) receptor 10 |
| Identity: |
4474 |
| Gene: |
CCR10 |
More about : CCR10 |
| Long gene name: |
C-C motif chemokine receptor 10 |
| Synonyms gene: |
GPR2 |
| Synonyms gene name: |
G protein-coupled receptor 2 chemokine (C-C motif) receptor 10 |
| Locus: |
17q21, 2 |
| Discovery year: |
1994-07-25 |
| GenBank acession: |
AF215981 |
| Entrez gene record: |
2826 |
| Pubmed identfication: |
7851889 |
| RefSeq identity: |
NM_016602 |
| Classification: |
C-C motif chemokine receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000132301 |