| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
PLGF |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
WB |
| Recommended dilutions: |
5-1ug/ml, Western blot: 0 |
| Notes: |
Titration of the PLGF antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use: |
This PLGF antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot #: |
P49763 |
| Purity: |
Antigen affinity |
| Description: |
It belongs to the family of vascular endothelial growth factors(VEGFs) and binds to the flt-1 VEGF receptor, It is a glycosylated dimeric secreted protein able to stimulate endothelial cell growth in vitro, Moreover, PGF is located on chromosome 14 and has been conserved in evolution, PGF regulates inter- and intra molecular cross talk between the VEGF RTKs Flt1 and Flk1 and stimulates the phosphorylation of specific Flt1 tyrosine residues and the expression of distinct downstream target genes, PLGF-2, also known as PLGF) codes for an angiogenic factor expressed in placental tissue that is similar to vascular permeability factor/vascular endothelial growth factor(VPF/VEGF), binds neuropilin-1 and 2 in a heparin-dependent manner, it plays an important role in pathological angiogenic events and with exerting its biological activities through binding to VEGFR1, which is a PLGF isoform, Placental growth factor(PGF |
| Immunogen: |
An amino acid sequence from the C-terminus of human PLGF (REKMKPERCGDAVPRR) was used as the immunogen for this PLGF antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the PLGF antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
PLGF |
| Short name: |
PLGF Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
PLGF (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
8893 |
| Gene: |
PGF |
More about : PGF |
| Long gene name: |
placental growth factor |
| Synonyms gene: |
PGFL |
| Synonyms gene name: |
placental growth factor-like placental growth factor, vascular endothelial growth factor-related protein |
| Synonyms: |
PLGF PlGF-2 PlGF SHGC-10760 D12S1900 PIGF |
| Synonyms name: |
placenta growth factor |
| Locus: |
14q24, 3 |
| Discovery year: |
1994-01-14 |
| GenBank acession: |
S72960 |
| Entrez gene record: |
5228 |
| Pubmed identfication: |
7681160 |
| RefSeq identity: |
NM_002632 |
| Classification: |
VEGF family |
| Havana BLAST/BLAT: |
OTTHUMG00000171496 |