| Category: |
Antibody |
| Concentration: |
2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form: |
Antigen affinity purified |
| Conjugation: |
Unconjugated |
| Clone: |
Polyclonal antibody |
| Recognised antigen: |
CBS |
| Host animal: |
Rabbit (Oryctolagus cuniculus) |
| Clonality: |
Polyclonal (rabbit origin) |
| Species reactivity: |
Due to limited knowledge and inability to test the antibody against all known species, Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0 |
| Notes: |
Titration of the CBS antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting points |
| Intented use: |
This CBS antibodyis to be used only for research purposes and not for diagnostics |
| Gene ID #: |
875 |
| Purity: |
Antigen affinity |
| Description: |
CBS catalyzes the first step of the transsulfuration pathway, It is a multidomain enzyme composed of an N-terminal enzymatic domain and two CBS domains, It is mapped to 21q22, It uses the cofactor pyridoxal-phosphate (PLP) and can be allosterically regulated by effectors such as the ubiquitous cofactor S-adenosyl-L-methionine (adoMet), The gene is the most common locus for mutations associated with homocystinuria, This enzyme belongs to the family of lyases, from homocysteine to cystathionine, ranging in size from 42 to 299 bp, the hydro-lyases, to be specific, which cleave carbon-oxygen bonds, 3 and contains 23 exons, Cystathionine-beta-synthase is an enzyme that in humans is encoded by the CBS gene |
| Immunogen: |
Human partial recombinant protein (AA 331-551) was used as the immunogen for this CBS antibody |
| Storage: |
Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the CBS antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target: |
CBS |
| Short name: |
CBS Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
CBS (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
1550 |
| Gene: |
CBS |
More about : CBS |
| Long gene name: |
cystathionine-beta-synthase |
| Synonyms: |
HIP4 |
| Locus: |
21q22, 3 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
L14577 |
| Entrez gene record: |
875 |
| Pubmed identfication: |
9790750 |
| RefSeq identity: |
NM_000071 |
| Havana BLAST/BLAT: |
OTTHUMG00000086834 |
| Locus Specific Databases: |
Cystathionine beta-synthase database LRG_777 |