| Long name: |
30, 33) Monoclonal Antibody, ABL2 (1442CT175 |
| Also known as: |
30, 33) Monoclonal Antibody, ABL2 (1442CT175 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
ABL2 |
| Specificity: |
This is a highly specific antibody against ABL2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
1442CT175, 30, 33 |
| Source: |
This ABL2 antibody is generated from a mouse immunized with a recombinant protein |
| Gene ID number: |
27 |
| Swiss Prot: |
P42684 |
| Tested Applications: |
IHC-P, WB |
| Recommended dilutions: |
WB(1:500-2000), IHC-P(1:25) |
| Cross reactivity: |
Mouse, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
ABI1, ABL2 acts also as a regulator of multiple pathological signaling cascades during infection, Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity, CRKL, CTTN (involved in signaling), Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement), DOK1 or ARHGAP35, Finally, In brain, Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1, cell motility and adhesion and receptor endocytosis, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, like facilitating intracellular movement and host cell exit, may regulate neurotransmission by phosphorylating proteins at the synapse, or TUBA1 and TUBB (microtubule subunits), resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO, Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
ABL2, ABLL, Abelson murine leukemia viral oncogene homolog 2, Abelson tyrosine-protein kinase 2, Abelson-related gene protein, Tyrosine-protein kinase ARG, ARG |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
30, 33) Monoclonal, ABL2 (1442CT175 |
| Short name: |
30, 33) Monoclonal Antibody, ABL2 (1442CT175 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
30, 33) monoclonal (Antibody to), v-abl Abelson murine leukemia viral oncogene homolog 2 (1442CT175 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ABL2 and IDBG-105099 and ENSG00000143322 and 27, ABLL and ARG, Abl2 and IDBG-200390 and ENSMUSG00000026596 and 11352, BT, Cytoplasm, this GO :0000287 and magnesium ion binding and molecular function this GO :0003785 and actin monomer binding and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004715 and non-membrane spanning protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005829 and cytosol and cellular component this GO :0006464 and cellular protein modification process and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0007015 and actin filament organization and biological process this GO :0007155 and cell adhesion and biological process this GO :0007165 and signal transduction and biological process this GO :0007411 and axon guidance and biological process this GO :0010506 and regulation of autophagy and biological process this GO :0010976 and positive regulation of neuron projection development and biological process this GO :0015629 and actin cytoskeleton and cellular component this GO :0016772 and transferase activity, this GO :0000287 : magnesium ion binding, this GO :0000287 : magnesium ion binding and also this GO :0003785 : actin monomer binding and also this GO :0004672 : protein kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004715 : non-membrane spanning protein tyrosine kinase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016772 : transferase activity, this GO :0003785 : actin monomer binding, this GO :0004672 : protein kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004715 : non-membrane spanning protein tyrosine kinase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016772 : transferase activity, this GO :0030145 : manganese ion binding, this GO :0051015 : actin filament binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0030145 : manganese ion binding and also this GO :0051015 : actin filament binding, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0030100 and regulation of endocytosis and biological process this GO :0030145 and manganese ion binding and molecular function this GO :0030155 and regulation of cell adhesion and biological process this GO :0051015 and actin filament binding and molecular function this GO :0051017 and actin filament bundle assembly and biological process this GO :0051353 and positive regulation of oxidoreductase activity and biological process this GO :0071300 and cellular response to retinoic acid and biological process this GO :2000145 and regulation of cell motility and biological process this GO :2000249 and regulation of actin cytoskeleton reorganization and biological process, 62162 and IDBG-636736 and ENSBTAG00000015026 and 511845, v-abl Abelson murine leukemia viral oncogene homolog 2 |
| Identity: |
77 |
| Gene: |
ABL2 |
More about : ABL2 |
| Long gene name: |
ABL proto-oncogene 2, non-receptor tyrosine kinase |
| Synonyms gene: |
ABLL |
| Synonyms gene name: |
Abelson-related gene) v-abl Abelson murine leukemia viral oncogene homolog 2 c-abl oncogene 2, non-receptor tyrosine kinase , v-abl Abelson murine leukemia viral oncogene homolog 2 (arg |
| Synonyms: |
ARG |
| Synonyms name: |
Abelson-related gene |
| Locus: |
1q25, 2 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
M14904 |
| Entrez gene record: |
27 |
| Pubmed identfication: |
3787260 |
| RefSeq identity: |
NM_005158 |
| Classification: |
SH2 domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000035199 |