| Long name: |
4) Monoclonal Antibody, 6, EPHB2 (48CT12 |
| Also known as: |
4) Monoclonal Antibody, 6, EPHB2 (48CT12 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
EPHB2 |
| Specificity: |
This is a highly specific antibody against EPHB2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
4, 48CT12, 6 |
| Source: |
between amino acids 127~425) was used to produce this monoclonal antibody, Purified His-tagged EPHB2 protein(Fragment |
| Gene ID number: |
2048 |
| Swiss Prot: |
P29323 |
| Tested Applications: |
FCM, IHC-P, WB |
| Recommended dilutions: |
FC(1:10~50), IHC-P(1:200), WB(1:1000) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk, Controls other aspects of development including angiogenesis, Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca, Functions in axon guidance during development, In addition to axon guidance, Involved in the guidance of commissural axons, May function as a tumor suppressor, The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling, Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses, leading to contact-dependent bidirectional signaling into neighboring cells, palate development and in inner ear development through regulation of endolymph production, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex, Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells |
| Purification method: |
This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0 |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CAPB, Developmentally-regulated Eph-related tyrosine kinase, EK5, ELK-related tyrosine kinase, EPH tyrosine kinase 3, EPH-like kinase 5, EPHB2, EPHT3, EPTH3, ERK, Ephrin type-B receptor 2, Hek5, PCBC, Renal carcinoma antigen NY-REN-47, Tyro5, Tyrosine-protein kinase TYRO5, Tyrosine-protein kinase receptor EPH-3, DRT |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
4) Monoclonal, 6, EPHB2 (48CT12 |
| Short name: |
4) Monoclonal Antibody, 6, EPHB2 (48CT12 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
4) monoclonal (Antibody to), 6, EPHB2 (48CT12 |
| Alternative technique: |
antibodies |
| Identity: |
3393 |
| Gene: |
EPHB2 |
More about : EPHB2 |
| Long gene name: |
EPH receptor B2 |
| Synonyms gene: |
DRT ERK EPHT3 |
| Synonyms gene name: |
EphB2 |
| Synonyms: |
Hek5 Tyro5 |
| Locus: |
1p36, 12 |
| Discovery year: |
1995-05-09 |
| GenBank acession: |
AF025304 |
| Entrez gene record: |
2048 |
| Pubmed identfication: |
1648701 |
| RefSeq identity: |
NM_017449 |
| Classification: |
Sterile alpha motif domain containing Fibronectin type III domain containing EPH receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000002881 |
| Locus Specific Databases: |
LRG_780 |