| Long name: |
118, 237) Monoclonal Antibody, FYN (1302CT390 |
| Also known as: |
118, 237) Monoclonal Antibody, FYN (1302CT390 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
FYN |
| Specificity: |
This is a highly specific antibody against FYN |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
118, 1302CT390, 237 |
| Source: |
This FYN antibody is generated from a mouse immunized with a recombinant preotein from human FYN |
| Gene ID number: |
2534 |
| Swiss Prot: |
P06241 |
| Tested Applications: |
FCM, IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:25), FC(1:25) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
ARHGAP32, Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, CSK maintains LCK and FYN in an inactive form, Following activation by PKA, Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain, Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin), KIRREL and TRPC6, Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation, Plays a role in neural processes by phosphorylating DPYSL2, Promotes CD28-induced phosphorylation of VAV1, Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage, Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT, a multifunctional adapter protein within the central nervous system, a regulator for Rho family GTPases implicated in various neural functions, a small pre-synaptic protein, activation and targeting to focal adhesions, allowing PTK2/FAK1 phosphorylation, and SNCA, cell adhesion, cell motility, cytoskeletal remodeling, immune response and axon guidance, integrin-mediated signaling, the protein subsequently associates with PTK2/FAK1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts, Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
FYN, Proto-oncogene Syn, Proto-oncogene c-Fyn, SYN, Src-like kinase, Tyrosine-protein kinase Fyn, p59-FYN, SLK |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
118, 237) Monoclonal, FYN (1302CT390 |
| Short name: |
118, 237) Monoclonal Antibody, FYN (1302CT390 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
FGR, YES (1302CT390, 118, 237) monoclonal (Antibody to), FYN oncogene related to v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
FGR, FYN and IDBG-631420 and ENSBTAG00000011851 and 527263, FYN and IDBG-95463 and ENSG00000010810 and 102724705, Fyn and IDBG-144629 and ENSMUSG00000019843 and 14360, YES, nuclei, p59-FYN and SLK and SYN, this GO :0001664 and G-protein coupled receptor binding and molecular function this GO :0001764 and neuron migration and biological process this GO :0001948 and glycoprotein binding and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004715 and non-membrane spanning protein tyrosine kinase activity and molecular function this GO :0005102 and receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005768 and endosome and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006816 and calcium ion transport and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007411 and axon guidance and biological process this GO :0007596 and blood coagulation and biological process this GO :0007612 and learning and biological process this GO :0007631 and feeding behavior and biological process this GO :0008360 and regulation of cell shape and biological process this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0010629 and negative regulation of gene expression and biological process this GO :0010976 and positive regulation of neuron projection development and biological process this GO :0014068 and positive regulation of phosphatidylinositol 3-kinase signaling and biological process this GO :0014069 and postsynaptic density and cellular component this GO :0015631 and tubulin binding and molecular function this GO :0016020 and membrane and cellular component this GO :0016032 and viral process and biological process this GO :0016772 and transferase activity, this GO :0001664 : G-protein coupled receptor binding, this GO :0001664 : G-protein coupled receptor binding and also this GO :0001948 : glycoprotein binding and also this GO :0004672 : protein kinase activity and also this GO :0004713 : protein tyrosine kinase activity and also this GO :0004715 : non-membrane spanning protein tyrosine kinase activity and also this GO :0005102 : receptor binding and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0015631 : tubulin binding and also this GO :0016772 : transferase activity, this GO :0001948 : glycoprotein binding, this GO :0004672 : protein kinase activity, this GO :0004713 : protein tyrosine kinase activity, this GO :0004715 : non-membrane spanning protein tyrosine kinase activity, this GO :0005102 : receptor binding, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0015631 : tubulin binding, this GO :0016772 : transferase activity, this GO :0032403 : protein complex binding, this GO :0042608 : T cell receptor binding, this GO :0042609 : CD4 receptor binding, this GO :0042610 : CD8 receptor binding, this GO :0043548 : phosphatidylinositol 3-kinase binding, this GO :0044325 : ion channel binding, this GO :0046872 : metal ion binding, this GO :0046875 : ephrin receptor binding, this GO :0051428 : peptide hormone receptor binding, this GO :0070851 : growth factor receptor binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0032403 : protein complex binding and also this GO :0042608 : T cell receptor binding and also this GO :0042609 : CD4 receptor binding and also this GO :0042610 : CD8 receptor binding and also this GO :0043548 : phosphatidylinositol 3-kinase binding and also this GO :0044325 : ion channel binding and also this GO :0046872 : metal ion binding and also this GO :0046875 : ephrin receptor binding and also this GO :0051428 : peptide hormone receptor binding and also this GO :0070851 : growth factor receptor binding, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0030168 and platelet activation and biological process this GO :0030900 and forebrain development and biological process this GO :0031295 and T cell costimulation and biological process this GO :0032403 and protein complex binding and molecular function this GO :0035556 and intracellular signal transduction and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0038096 and Fc-gamma receptor signaling pathway involved in pha this GO cytosis and biological process this GO :0042177 and negative regulation of protein catabolic process and biological process this GO :0042493 and response to drug and biological process this GO :0042608 and T cell receptor binding and molecular function this GO :0042609 and CD4 receptor binding and molecular function this GO :0042610 and CD8 receptor binding and molecular function this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0043548 and phosphatidylinositol 3-kinase binding and molecular function this GO :0044325 and ion channel binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045121 and membrane raft and cellular component this GO :0045471 and response to ethanol and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0046872 and metal ion binding and molecular function this GO :0046875 and ephrin receptor binding and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0048813 and dendrite morphogenesis and biological process this GO :0050690 and regulation of defense response to virus by virus and biological process this GO :0050798 and activated T cell proliferation and biological process this GO :0050852 and T cell receptor signaling pathway and biological process this GO :0050900 and leukocyte migration and biological process this GO :0050966 and detection of mechanical stimulus involved in sensory perception of pain and biological process this GO :0051428 and peptide hormone receptor binding and molecular function this GO :0070851 and growth factor receptor binding and molecular function this GO :0071363 and cellular response to growth factor stimulus and biological process this GO :0071375 and cellular response to peptide hormone stimulus and biological process this GO :1900182 and positive regulation of protein localization to nucleus and biological process this GO :2001240 and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, 2534, FYN oncogene related to SRC |
| Identity: |
4037 |
| Gene: |
FYN |
More about : FYN |
| Long gene name: |
FYN proto-oncogene, Src family tyrosine kinase |
| Synonyms gene name: |
FGR, FYN oncogene related to SRC, YES |
| Synonyms: |
SYN SLK MGC45350 |
| Locus: |
6q21 |
| Discovery year: |
1988-08-19 |
| GenBank acession: |
AK056699 |
| Entrez gene record: |
2534 |
| Pubmed identfication: |
3526330 |
| Classification: |
SH2 domain containing Src family tyrosine kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000016305 |