| Long name: |
130, 218) Monoclonal Antibody, BBS4 (1292CT845 |
| Also known as: |
130, 218) Monoclonal Antibody, BBS4 (1292CT845 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
BBS4 |
| Specificity: |
This is a highly specific antibody against BBS4 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
1292CT845, 130, 218 |
| Source: |
This BBS4 antibody is generated from a mice immunized with a recombinant protein between 1-240 amino acids from human BBS4 |
| Gene ID number: |
585 |
| Swiss Prot: |
Q96RK4 |
| Tested Applications: |
WB |
| Recommended dilutions: |
WB(1:1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome, Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane, Required for microtubule anchoring at the centrosome but not for microtubule nucleation, Required for proper BBSome complex assembly and its ciliary localization, The BBSome complex, The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function, This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane, together with the LTZL1, which localizes to the basal body and contacts the BBSome, The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia |
| Purification method: |
This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0 |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
BBS4, Bardet-Biedl syndrome 4 protein |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
130, 218) Monoclonal, BBS4 (1292CT845 |
| Short name: |
130, 218) Monoclonal Antibody, BBS4 (1292CT845 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
130, 218) monoclonal (Antibody to), Bardet-Biedl syndrome 4 (1292CT845 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BBS4 and IDBG-20881 and ENSG00000140463 and 585, BBS4 and IDBG-645611 and ENSBTAG00000007614 and 532120, Bbs4 and IDBG-172547 and ENSMUSG00000025235 and 102774, beta-tubulin binding, multiple, this GO :0000226 and microtubule cytoskeleton organization and biological process this GO :0000242 and pericentriolar material and cellular component this GO :0000281 and mitotic cytokinesis and biological process this GO :0001103 and RNA polymerase II repressing transcription factor binding and molecular function this GO :0001843 and neural tube closure and biological process this GO :0001895 and retina homeostasis and biological process this GO :0001947 and heart looping and biological process this GO :0003085 and negative regulation of systemic arterial blood pressure and biological process this GO :0003777 and microtubule motor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005813 and centrosome and cellular component this GO :0005814 and centriole and cellular component this GO :0005929 and cilium and cellular component this GO :0007286 and spermatid development and biological process this GO :0007601 and visual perception and biological process this GO :0007608 and sensory perception of smell and biological process this GO :0008104 and protein localization and biological process this GO :0008152 and metabolic process and biological process this GO :0010629 and negative regulation of gene expression and biological process this GO :0015031 and protein transport and biological process this GO :0016358 and dendrite development and biological process this GO :0019216 and regulation of lipid metabolic process and biological process this GO :0021756 and striatum development and biological process this GO :0021766 and hippocampus development and biological process this GO :0021987 and cerebral cortex development and biological process this GO :0030534 and adult behavior and biological process this GO :0031513 and nonmotile primary cilium and cellular component this GO :0031514 and motile cilium and cellular component this GO :0032402 and melanosome transport and biological process this GO :0032465 and regulation of cytokinesis and biological process this GO :0033210 and leptin-mediated signaling pathway and biological process this GO :0033365 and protein localization to organelle and biological process this GO :0034451 and centriolar satellite and cellular component this GO :0034452 and dynactin binding and molecular function this GO :0034454 and microtubule anchoring at centrosome and biological process this GO :0034464 and BBSome and cellular component this GO :0035058 and nonmotile primary cilium assembly and biological process this GO :0036064 and ciliary basal body and cellular component this GO :0038108 and negative regulation of appetite by leptin-mediated signaling pathway and biological process this GO :0040018 and positive regulation of multicellular organism growth and biological process this GO :0042384 and cilium assembly and biological process this GO :0043014 and alpha-tubulin binding and molecular function this GO :0044321 and response to leptin and biological process this GO :0045444 and fat cell differentiation and biological process this GO :0045494 and photoreceptor cell maintenance and biological process this GO :0045724 and positive regulation of cilium assembly and biological process this GO :0046548 and retinal rod cell development and biological process this GO :0046907 and intracellular transport and biological process this GO :0048487 and beta-tubulin binding and molecular function this GO :0048854 and brain morphogenesis and biological process this GO :0050893 and sensory processing and biological process this GO :0051297 and centrosome organization and biological process this GO :0051457 and maintenance of protein location in nucleus and biological process this GO :0051877 and pigment granule aggregation in cell center and biological process this GO :0060027 and convergent extension involved in gastrulation and biological process this GO :0060170 and ciliary membrane and cellular component this GO :0060271 and cilium morphogenesis and biological process this GO :0060296 and regulation of cilium beat frequency involved in ciliary motility and biological process this GO :0071539 and protein localization to centrosome and biological process, this GO :0001103 : RNA polymerase II repressing transcription factor binding, this GO :0001103 : RNA polymerase II repressing transcription factor binding and also this GO :0003777 : microtubule motor activity and also this GO :0005515 : protein binding and also this GO :0034452 : dynactin binding and also this GO :0043014 : alpha-tubulin binding and also this GO :0048487 : beta-tubulin binding, this GO :0003777 : microtubule motor activity, this GO :0005515 : protein binding, this GO :0034452 : dynactin binding, this GO :0043014 : alpha-tubulin binding, this GO :0048487 : beta-tubulin binding, Bardet-Biedl syndrome 4 |
| Identity: |
969 |
| Gene: |
BBS4 |
More about : BBS4 |
| Long gene name: |
Bardet-Biedl syndrome 4 |
| Locus: |
15q24, 1 |
| Discovery year: |
1995-07-11 |
| GenBank acession: |
AF090947 |
| Entrez gene record: |
585 |
| Pubmed identfication: |
7711739 11381270 |
| RefSeq identity: |
NM_033028 |
| Classification: |
Bardet-Biedl syndrome associated Tetratricopeptide repeat domain containing BBSome |
| Havana BLAST/BLAT: |
OTTHUMG00000133510 |
| Locus Specific Databases: |
Mutations of the Bardet-Biedl Syndrome Type 4 Gene |