| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
BBS4 |
| Specificity: |
This antibody reacts specifically with BBS4 |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human BBS4 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
BBS genes map to eight genetic loci and encode eight proteins, BBS is a heterogeneous disorder, BBS1-BBS8, BBS4 is expressed in the olfactory epithelium and localizes to the centriolar satellites of centrosomes and basal bodies of primary cilia, BBS4 regulates the p150 subunit of the dynein transport machinery (DCTN1) to attract pericentriolar material-1 protein (PCM1) and its associated components to the satellites, Five BBS genes encode basal body or cilia proteins, Loss of BBS4 is correlated with obesity caused by abnormal lipid profiles, Other associated clinical findings in BBS patients include diabetes, and abnormal leptin levels, and congenital heart defects, and developmental delay, elevated insulin, hypertension, hypogenitalism, liver dysfunction, photoreceptor degeneration, polydactyly, renal abnormalities, suggesting that BBS is a ciliary dysfunction disorder, Bardet-Biedl syndrome (BBS) is a pleiotropic genetic disorder characterized by obesity |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Also known as: |
BBS4 Polyclonal Antibody |
| Other name: |
Anti-BBS4 Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
BBS4 |
| Short name: |
Anti-BBS4 (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Bardet-Biedl syndrome 4 (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
BBS4 and IDBG-20881 and ENSG00000140463 and 585, BBS4 and IDBG-645611 and ENSBTAG00000007614 and 532120, Bbs4 and IDBG-172547 and ENSMUSG00000025235 and 102774, beta-tubulin binding, multiple, this GO :0000226 and microtubule cytoskeleton organization and biological process this GO :0000242 and pericentriolar material and cellular component this GO :0000281 and mitotic cytokinesis and biological process this GO :0001103 and RNA polymerase II repressing transcription factor binding and molecular function this GO :0001843 and neural tube closure and biological process this GO :0001895 and retina homeostasis and biological process this GO :0001947 and heart looping and biological process this GO :0003085 and negative regulation of systemic arterial blood pressure and biological process this GO :0003777 and microtubule motor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005813 and centrosome and cellular component this GO :0005814 and centriole and cellular component this GO :0005929 and cilium and cellular component this GO :0007286 and spermatid development and biological process this GO :0007601 and visual perception and biological process this GO :0007608 and sensory perception of smell and biological process this GO :0008104 and protein localization and biological process this GO :0008152 and metabolic process and biological process this GO :0010629 and negative regulation of gene expression and biological process this GO :0015031 and protein transport and biological process this GO :0016358 and dendrite development and biological process this GO :0019216 and regulation of lipid metabolic process and biological process this GO :0021756 and striatum development and biological process this GO :0021766 and hippocampus development and biological process this GO :0021987 and cerebral cortex development and biological process this GO :0030534 and adult behavior and biological process this GO :0031513 and nonmotile primary cilium and cellular component this GO :0031514 and motile cilium and cellular component this GO :0032402 and melanosome transport and biological process this GO :0032465 and regulation of cytokinesis and biological process this GO :0033210 and leptin-mediated signaling pathway and biological process this GO :0033365 and protein localization to organelle and biological process this GO :0034451 and centriolar satellite and cellular component this GO :0034452 and dynactin binding and molecular function this GO :0034454 and microtubule anchoring at centrosome and biological process this GO :0034464 and BBSome and cellular component this GO :0035058 and nonmotile primary cilium assembly and biological process this GO :0036064 and ciliary basal body and cellular component this GO :0038108 and negative regulation of appetite by leptin-mediated signaling pathway and biological process this GO :0040018 and positive regulation of multicellular organism growth and biological process this GO :0042384 and cilium assembly and biological process this GO :0043014 and alpha-tubulin binding and molecular function this GO :0044321 and response to leptin and biological process this GO :0045444 and fat cell differentiation and biological process this GO :0045494 and photoreceptor cell maintenance and biological process this GO :0045724 and positive regulation of cilium assembly and biological process this GO :0046548 and retinal rod cell development and biological process this GO :0046907 and intracellular transport and biological process this GO :0048487 and beta-tubulin binding and molecular function this GO :0048854 and brain morphogenesis and biological process this GO :0050893 and sensory processing and biological process this GO :0051297 and centrosome organization and biological process this GO :0051457 and maintenance of protein location in nucleus and biological process this GO :0051877 and pigment granule aggregation in cell center and biological process this GO :0060027 and convergent extension involved in gastrulation and biological process this GO :0060170 and ciliary membrane and cellular component this GO :0060271 and cilium morphogenesis and biological process this GO :0060296 and regulation of cilium beat frequency involved in ciliary motility and biological process this GO :0071539 and protein localization to centrosome and biological process, this GO :0001103 : RNA polymerase II repressing transcription factor binding, this GO :0001103 : RNA polymerase II repressing transcription factor binding and also this GO :0003777 : microtubule motor activity and also this GO :0005515 : protein binding and also this GO :0034452 : dynactin binding and also this GO :0043014 : alpha-tubulin binding and also this GO :0048487 : beta-tubulin binding, this GO :0003777 : microtubule motor activity, this GO :0005515 : protein binding, this GO :0034452 : dynactin binding, this GO :0043014 : alpha-tubulin binding, this GO :0048487 : beta-tubulin binding, Bardet-Biedl syndrome 4 |
| Identity: |
969 |
| Gene: |
BBS4 |
More about : BBS4 |
| Long gene name: |
Bardet-Biedl syndrome 4 |
| Locus: |
15q24, 1 |
| Discovery year: |
1995-07-11 |
| GenBank acession: |
AF090947 |
| Entrez gene record: |
585 |
| Pubmed identfication: |
7711739 11381270 |
| RefSeq identity: |
NM_033028 |
| Classification: |
Bardet-Biedl syndrome associated Tetratricopeptide repeat domain containing BBSome |
| Havana BLAST/BLAT: |
OTTHUMG00000133510 |
| Locus Specific Databases: |
Mutations of the Bardet-Biedl Syndrome Type 4 Gene |