| Long name: |
2) Monoclonal Antibody, 9, NOTCH3 (487CT6 |
| Also known as: |
2) Monoclonal Antibody, 9, NOTCH3 (487CT6 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
NOTCH3 |
| Specificity: |
This is a highly specific antibody against NOTCH3 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
2, 487CT6, 9 |
| Source: |
This NOTCH3 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 2291-2321 amino acids from the C-terminal region of human NOTCH3 |
| Gene ID number: |
4854 |
| Swiss Prot: |
Q9UM47 |
| Tested Applications: |
WB |
| Recommended dilutions: |
WB(1:100~250) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Affects the implementation of differentiation, Jagged2 and Delta1 to regulate cell-fate determination, Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus, proliferation and apoptotic programs (By similarity), Functions as a receptor for membrane-bound ligands Jagged1 |
| Purification method: |
This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0 |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CADASIL, CADASIL1, CASIL, LMNS, NOTCH3, Neurogenic locus notch homolog protein 3, Notch 3, IMF2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
2) Monoclonal, 9, NOTCH3 (487CT6 |
| Short name: |
2) Monoclonal Antibody, 9, NOTCH3 (487CT6 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
2) monoclonal (Antibody to), 9, NOTCH3 (487CT6 |
| Alternative technique: |
antibodies |
| Identity: |
7883 |
| Gene: |
NOTCH3 |
More about : NOTCH3 |
| Long gene name: |
notch 3 |
| Synonyms gene: |
CADASIL |
| Synonyms gene name: |
Notch (Drosophila) homolog 3 Notch homolog 3 (Drosophila) |
| Synonyms: |
CASIL |
| Locus: |
19p13, 12 |
| Discovery year: |
1994-07-04 |
| GenBank acession: |
U97669 |
| Entrez gene record: |
4854 |
| Pubmed identfication: |
7835890 |
| RefSeq identity: |
NM_000435 |
| Classification: |
Ankyrin repeat domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000183217 |
| Locus Specific Databases: |
NOTCH3 - CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical LOVD - Leiden Open Variation Database |