| Long name: |
86) Monoclonal Antibody, SET07 (43AT551 |
| Also known as: |
86) Monoclonal Antibody, SET07 (43AT551 |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
SET07 |
| Specificity: |
This is a highly specific antibody against SET07 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
43AT551, 86 |
| Source: |
This SET07 antibody was raised using purified recombinant GST fusion protein encoding the N-terminal region of human SET07 |
| Gene ID number: |
387893 |
| Swiss Prot: |
Q9NQR1 |
| Tested Applications: |
IF, IHC-P, WB |
| Recommended dilutions: |
IF(1:10~50), IHC-P(1:10~50), WB(1:1000) |
| Cross reactivity: |
Mouse, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression, Involved in chromosome condensation and proper cytokinesis, Mainly functions in euchromatin regions, Mediates monomethylation of p53/TP53 at 'Lys-382', Nucleosomes are preferred as substrate compared to free histones, Plays a negative role in TGF-beta response regulation and a positive role in cell migration, Required for cell proliferation, Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1), leading to repress p53/TP53-target genes, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis, thereby playing a central role in the silencing of euchromatic genes, Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins |
| Purification method: |
This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0 |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
H4-K20-HMTase KMT5A, Histone-lysine N-methyltransferase KMT5A, KMT5A, Lysine N-methyltransferase 5A, Lysine-specific methylase 5A, N-lysine methyltransferase KMT5A, PR-Set7, PR/SET domain-containing protein 07, PR/SET07, PRSET7, SET domain-containing protein 8, SET07, SETD8, SET8 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
86) Monoclonal, SET07 (43AT551 |
| Short name: |
86) Monoclonal Antibody, SET07 (43AT551 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
86) monoclonal (Antibody to), SET07 (43AT551 |
| Alternative technique: |
antibodies |
| Identity: |
29489 |
| Gene: |
KMT5A |
More about : KMT5A |
| Long gene name: |
lysine methyltransferase 5A |
| Synonyms gene: |
SETD8 |
| Synonyms gene name: |
SET domain containing (lysine methyltransferase) 8 lysine (K)-specific methyltransferase 5A |
| Synonyms: |
SET8 SET07 PR-Set7 |
| Locus: |
12q24, 31 |
| Discovery year: |
2006-02-15 |
| GenBank acession: |
AY102937 |
| Entrez gene record: |
387893 |
| Pubmed identfication: |
15933070 12086618 12121615 |
| RefSeq identity: |
NM_020382 |
| Classification: |
Lysine methyltransferases |
| Havana BLAST/BLAT: |
OTTHUMG00000150477 |