| Long name: |
RIP2 (AF28D3) Monoclonal Antibody |
| Also known as: |
RIP2 (AF28D3) Monoclonal Antibody |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
RIP2 |
| Specificity: |
This is a highly specific antibody against RIP2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
AF28D3 |
| Concentration: |
1ug per 1ul |
| Source: |
Recombinant human protein purified from E, coli (His-RIP2) |
| Gene ID number: |
8767 |
| Swiss Prot: |
O43353 |
| Tested Applications: |
IP, WB |
| Recommended dilutions: |
000) IP (3 ul), WB (1:2 |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
BIRC2 and BIRC3, Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2, In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, NOD1 and NOD2 are activated, Once recruited, Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB, Upon stimulation by bacterial peptidoglycans, growth control, oligomerize and recruit RIPK2 through CARD-CARD domains, or protection against apoptosis, Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses |
| Purification method: |
Purified by Protein G |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CARD-containing IL-1 beta ICE-kinase, CARD-containing interleukin-1 beta-converting enzyme-associated kinase, CARD3, CARDIAK, GIG30, RICK, RIP-2, RIP-like-interacting CLARP kinase, RIP2, RIPK2, Receptor-interacting protein 2, Receptor-interacting serine/threonine-protein kinase 2, Tyrosine-protein kinase RIPK2, UNQ277/PRO314/PRO34092, CCK |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
RIP2 (AF28D3) Monoclonal |
| Short name: |
RIP2 (AF28D3) Monoclonal Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
RIP2 (AF28D3) monoclonal (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
30322 |
| Gene: |
ARHGEF28 |
More about : ARHGEF28 |
| Long gene name: |
Rho guanine nucleotide exchange factor 28 |
| Synonyms gene name: |
Rho guanine nucleotide exchange factor (GEF) 28 |
| Synonyms: |
RGNEF p190RhoGEF RIP2 |
| Locus: |
5q13, 2 |
| Discovery year: |
2012-08-08 |
| Entrez gene record: |
64283 |
| Pubmed identfication: |
9199174 11058585 |
| Havana BLAST/BLAT: |
OTTHUMG00000162454 |