| Long name: |
RSK2/3 (3C1) Monoclonal Antibody |
| Also known as: |
RSK2/3 (3C1) Monoclonal Antibody |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
RSK2/3 |
| Specificity: |
This is a highly specific antibody against RSK2/3 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
3C1 |
| Concentration: |
2ug/ul |
| Source: |
), Recombinant human protein purified from E, a, coli(His/ABD-RSK3 415-733 a |
| Gene ID number: |
6197 |
| Swiss Prot: |
P51812 |
| Tested Applications: |
WB |
| Recommended dilutions: |
0 ug/mL), WB (2 |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Addition of growth factor to the cells results in the activation of both cytosolic and nuclear RSK and the translocation of the cytosolic RSK into the nucleus upon activation, ERK activates the C-terminal kinase of RSK, In humans, Members of the RSK family are present in the cytoplasm as well as the nucleus, NFkappaB/IkappaB &alpha, RSK family members are unusual among serine/threonine kinases in that they contain two distinct kinase domains, RSK regulates gene expression via association and phosphorylation of transcriptional regulators including c-Fos, The activation and nuclear translocation of RSK result in phosphorylation and activation of transcription factors, Theses kinase dimains are activated in a sequential manner by a series of phosphorylations, both of which are catalytically functional, cAMP-response element-binding protein (CREB), estrogen receptor, leading to activation of the N-terminal kinase, the RSK family consists of four isoforms (RSK1 to -4), The p90 ribosomal S6 kinases (RSKs) comprise a family of serine/threonine kinases that lie at the terminus of the ERK pathway |
| Purification method: |
Purified by Protein G |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
90 kDa ribosomal protein S6 kinase 3, HU-3, ISPK-1, ISPK1, Insulin-stimulated protein kinase 1, MAP kinase-activated protein kinase 1b, MAPK-activated protein kinase 1b, MAPKAP kinase 1b, MAPKAPK-1b, MAPKAPK1B, MRX19, RPS6KA3, RSK, RSK-2, RSK2, Ribosomal S6 kinase 2, Ribosomal protein S6 kinase alpha-3, S6K-alpha-3, S6K-alpha3, p90-RSK 3, p90-RSK2, p90RSK3, pp90RSK2, CLS |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
RSK2/3 (3C1) Monoclonal |
| Short name: |
RSK2/3 (3C1) Monoclonal Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
RSK2/3 (3C1) monoclonal (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
10432 |
| Gene: |
RPS6KA3 |
More about : RPS6KA3 |
| Long gene name: |
ribosomal protein S6 kinase A3 |
| Synonyms gene: |
MRX19 CLS |
| Synonyms gene name: |
90kD, polypeptide 3 , ribosomal protein S6 kinase |
| Synonyms: |
RSK RSK2 HU-3 |
| Locus: |
Xp22, 12 |
| Discovery year: |
1994-07-11 |
| GenBank acession: |
U08316 |
| Entrez gene record: |
6197 |
| Pubmed identfication: |
8141249 11896450 16879200 |
| RefSeq identity: |
NM_004586 |
| Classification: |
X-linked mental retardation Mitogen-activated protein kinase-activated protein kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000021231 |
| Locus Specific Databases: |
Mental Retardation database |