| Long name: |
TRBP (46D1) Monoclonal Antibody |
| Also known as: |
TRBP (46D1) Monoclonal Antibody |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
TRBP |
| Specificity: |
This is a highly specific antibody against TRBP |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
46D1 |
| Concentration: |
1ug per 1ul |
| Source: |
Recombinant human protein purified from E, coli(GST-TRBP) |
| Gene ID number: |
6895 |
| Swiss Prot: |
Q15633 |
| Tested Applications: |
WB |
| Recommended dilutions: |
5 ug/mL), WB (0 |
| Cross reactivity: |
Mouse, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
AGO2 and TARBP2, AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2, Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, Component of the RISC loading complex (RLC), DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2, May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1, May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR, This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, Within the RLC/miRLC, also known as the micro-RNA (miRNA) loading complex (miRLC), and stimulates translation of TAR-containing RNAs, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha, which is composed of DICER1, Required for formation of the RNA induced silencing complex (RISC) |
| Purification method: |
Purified by Protein G |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
RISC-loading complex subunit TARBP2, TAR RNA-binding protein 2, TARBP2, TRBP, TRBP1, TRBP2, Trans-activation-responsive RNA-binding protein, LOQS |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
TRBP (46D1) Monoclonal |
| Short name: |
TRBP (46D1) Monoclonal Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TRBP (46D1) monoclonal (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11570 |
| Gene: |
TARBP2P1 |
More about : TARBP2P1 |
| Long gene name: |
RISC loading complex RNA binding subunit pseudogene 1 , TARBP2P1 |
| Synonyms gene: |
TARBP2P |
| Synonyms gene name: |
Tar (HIV-1) RNA binding protein 2 pseudogene TAR (HIV-1) RNA binding protein 2 pseudogene 1 |
| Synonyms: |
TRBP |
| Locus: |
8q22, 3 |
| Discovery year: |
1994-04-12 |
| GenBank acession: |
AF197477 |
| Entrez gene record: |
6896 |
| Pubmed identfication: |
2011739 |
| RefSeq identity: |
NG_001199 |