| Long name: |
p90RSK1 (8C12) Monoclonal Antibody |
| Also known as: |
p90RSK1 (8C12) Monoclonal Antibody |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
RSK1 (P90RSK1) |
| Specificity: |
This is a highly specific antibody against RSK1 (P90RSK1) |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
8C12 |
| Concentration: |
2ug/ul |
| Source: |
Recombinant human protein purified from E, coli (His-RSK1) |
| Gene ID number: |
6195 |
| Swiss Prot: |
Q15418 |
| Tested Applications: |
IP, WB |
| Recommended dilutions: |
0 ug), 0 ug/ml) IP (5, WB (2 |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
ETV1/ER81 and NR4A1/NUR77, In fibroblast, In response to insulin, In response to mitogenic stimulation (EGF and PMA), Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function, Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex, Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4), Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1, and mediates cellular proliferation, and mediates phosphorylation of RPTOR, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation, is required for EGF-stimulated phosphorylation of CREB1, phosphorylates EIF4B, phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP, regulates translation through RPS6 and EIF4B phosphorylation, survival, which potently inhibits TSC2 ability to suppress mTOR signaling, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway, which results in the subsequent transcriptional activation of several immediate-early genes, Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1 |
| Purification method: |
Purified by Protein G |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
90 kDa ribosomal protein S6 kinase 1, HU-1, MAP kinase-activated protein kinase 1a, MAPK-activated protein kinase 1a, MAPKAP kinase 1a, MAPKAPK-1a, MAPKAPK1A, RPS6KA1, RSK-1, RSK1, Ribosomal S6 kinase 1, Ribosomal protein S6 kinase alpha-1, S6K-alpha-1, p90-RSK 1, p90RSK1, p90Rsk, p90S6K, RSK |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
p90RSK1 (8C12) Monoclonal |
| Short name: |
p90RSK1 (8C12) Monoclonal Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
p90RSK1 (8C12) monoclonal (Antibody to) |
| Alternative technique: |
antibodies |