| Long name: |
Ubiquitin (2A1) Monoclonal Antibody |
| Also known as: |
Ubiquitin (2A1) Monoclonal Antibody |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Ubiquitin |
| Specificity: |
This is a highly specific antibody against Ubiquitin |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Monoclonal |
| Clone number: |
2A1 |
| Source: |
GST-fusion recombinant Human ubiquitin protein purified from E, coli |
| Gene ID number: |
7311 |
| Swiss Prot: |
P62987 |
| Tested Applications: |
IP, WB |
| Recommended dilutions: |
WB (1:2000) IP (2 ul) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
60S ribosomal protein L40: Component of the 60S subunit of the ribosome, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B, Linear polymer chains formed via attachment by the initiator Met lead to cell signaling, Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation, Lys-29-linked is involved in lysosomal degradation, Lys-33-linked is involved in kinase modification, Lys-48-linked is involved in protein degradation via the proteasome, Lys-63-linked is involved in endocytosis, Polyubiquitin chains, Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, Ubiquitin is usually conjugated to Lys residues of target proteins, When covalently bound, When polyubiquitin is free (unanchored-polyubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains), and especially for cap-dependent translation of vesicular stomatitis virus mRNAs, and in signaling, conjugation to Cys or Ser residues has been observed, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair, however, in rare cases, it also has distinct roles, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), or free (unanchored), such as in activation of protein kinases, when attached to a target protein, Ubiquitin: Exists either covalently attached to another protein |
| Purification method: |
Ammonium sulfate precipitation |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CEP52, HUBCEP52, RPL40, UBA52, UBCEP2, Ubiquitin A-52 residue ribosomal protein fusion product 1, Ubiquitin-60S ribosomal protein L40, L40 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target: |
Ubiquitin (2A1) Monoclonal |
| Short name: |
Ubiquitin (2A1) Monoclonal Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Ubiquitin (2A1) monoclonal (Antibody to) |
| Alternative technique: |
antibodies |