| Also known as: |
MUC16 / CA125 |
| Other names: |
CA-125, Mucin-16, N/A, N/A, Ovarian cancer-related tumor marker CA125, Ovarian carcinoma antigen CA125, mucin-16 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
MUC16 |
| Gene name synonims: |
CA125 |
| Other gene names: |
CA-125, CA125, MUC-16, MUC16, N/A, N/A |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
X75 (3C8/4) |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
CA-125 was originally identified by Bast et al, Mucin 16 is a serum marker, Recognizes epitope specificity group B (ISOBM classification) similar to M-11, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, also known as Ovarian Cancer Antigen CA-125, overexpressed in epithelial ovarian cancer cells and is routinely used for patient monitoring, using a monoclonal antibody developed against the ovarian cancer cell line OVCA433, Specific for Mucin 16 |
| Purification method: |
Ion exchange Chromatography |
| Form/Appearance: |
0, 09% sodium azide, Tris buffered saline |
| Concentration: |
1 miligram per 1 mililiter |
| Storage and shipping: |
Cycles of freezing/defrosting can damage the peptide chains of the antibodies thus reducing the activity, Short term storage of the antibody can be done at +4 degrees Celsius, keep the antibody at -20 degrees Celsius, For long term storage |
| Tested applications:: |
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC - Paraffin) |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| Gene target: |
Monoclonal [ X75 (3C8/4)] (IgG1) MUC16 / CA125 |
| Short name: |
Mouse Monoclonal [clone X75 (3C8/4)] (IgG1) MUC16 / CA125 Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype: |
IgG1 |
| Species: |
Humans, Mouses, Human |
| Alternative name: |
cellular surface associated / CA125 (Antibody to), sapiens mucin 16, Mouse monoclonal [clonality X75 (3C8/4)] (IgG1) to H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Extracellular, MUC16 and IDBG-25369 and ENSG00000181143 and 94025, MUC16 and IDBG-643029 and ENSBTAG00000037693 and 786607, Muc16 and IDBG-136368 and ENSMUSG00000032134 and 73732, cell surface associated, this GO :0005615 and extracellular space and cellular component this GO :0009897 and external side of plasma membrane and cellular component, mucin 16 |
| Identity: |
15582 |
| Gene: |
MUC16 |
More about : MUC16 |
| Long gene name: |
cell surface associated , mucin 16 |
| Synonyms: |
CA125 FLJ14303 |
| Locus: |
19p13, 2 |
| Discovery year: |
2001-07-20 |
| GenBank acession: |
AF414442 |
| Entrez gene record: |
94025 |
| Pubmed identfication: |
11369781 |
| RefSeq identity: |
NM_024690 |
| Classification: |
Mucins |
| Havana BLAST/BLAT: |
OTTHUMG00000169191 |