| Also known as: |
HLA-E |
| Other names: |
E, E alpha chain, HLA class I histocompatibility antigen, HLA class I histocompatibility antigen, HLA class I histocompatibility antigen, MHC HLA-E alpha-1, MHC HLA-E alpha-2, MHC class I antigen E, MHC class I antigen E, alpha chain E, alpha chain E, alpha chain E, class I, lymphocyte antigen, major histocompatibility complex, 1, HLA class I histocompatibility antigen |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
HLA-E |
| Other gene names: |
EA1, EA2, HLA-6, HLA-6, HLA-E, HLAE, MHC, QA1, 1, 2, 2, 2, HLA-E |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
MEM-E/07 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
-B44 (weakly), HLA-B27, HLA-B8 (moderately), HLA-E belongs to the MHC Class I molecules (MHC Class Ib, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The published results revealed that the antibody cross-reacts with some classical MHC Class I molecules (MHC Class Ia): HLA-B7 (strongly), This particular antibody might cross react with speacies outside of the listed ones, but not denatured heavy chain of HLA-E, nonclassical) and it is expressed on many types of the human cells, Recognized native surface-expressed HLA-E |
| Purification method: |
Protein A Purified |
| Form/Appearance: |
15 mM sodium azide, approx, pH 7, 4, PBS |
| Storage and shipping: |
For long term storage aliquot and keep the antibody at -20 degrees Celsius, Freeze-thaw cycles should be avoided in order to retain the activity of the antibody, Store at +4 degrees Celsius for short term storage |
| Tested applications:: |
Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Immunohistochemistry (IHC - Paraffin) |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| Gene target: |
Monoclonal [ MEM-E/07] (IgG1) HLA-E |
| Short name: |
Mouse Monoclonal [clone MEM-E/07] (IgG1) HLA-E Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype: |
IgG1 |
| Species: |
Humans, Mouses, Human |
| Alternative name: |
E (Antibody to), class I, sapiens major histocompatibility complex, Mouse monoclonal [clonality MEM-E/07] (IgG1) to H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
E, EA1, HLA-E and IDBG-125081 and ENSG00000204592 and 3133, Plasma membranes, class I, peptide antigen binding, this GO :0001916 and positive regulation of T cell mediated cytotoxicity and biological process this GO :0002474 and antigen processing and presentation of peptide antigen via MHC class I and biological process this GO :0005515 and protein binding and molecular function this GO :0006955 and immune response and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0019882 and antigen processing and presentation and biological process this GO :0042605 and peptide antigen binding and molecular function this GO :0042612 and MHC class I protein complex and cellular component, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0042605 : peptide antigen binding, this GO :0042605 : peptide antigen binding, 1 and HLA-6, 2 and EA2, 2 and MHC and QA1, major histocompatibility complex |
| Identity: |
4962 |
| Gene: |
HLA-E |
More about : HLA-E |
| Long gene name: |
E , class I, major histocompatibility complex |
| Locus: |
6p22, 1 |
| Discovery year: |
1988-05-11 |
| GenBank acession: |
M20022 |
| Entrez gene record: |
3133 |
| Pubmed identfication: |
3131426 |
| RefSeq identity: |
NM_005516 |
| Classification: |
C1-set domain containing Histocompatibility complex |
| Havana BLAST/BLAT: |
OTTHUMG00000031155 |
| Locus Specific Databases: |
IMGT/HLA Database |