| Also known as: |
MCP / CD46 |
| Other names: |
CD46 antigen, CD46 molecule, CD_antigen: CD46, Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen, antigen identified by monoclonal antibody TRA-2-10, complement membrane cofactor protein, complement regulatory protein, complement regulatory protein, measles virus receptor, membrane cofactor protein, membrane cofactor protein (CD46, trophoblast leucocyte common antigen, trophoblast leukocyte common antigen, trophoblast-lymphocyte cross-reactive antigen, trophoblast-lymphocyte cross-reactive antigen), membrane cofactor protein isoform 1 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
MCP |
| Gene name synonims: |
CD46 |
| Other gene names: |
AHUS2, CD46, MCP, MCP, MIC10, MIC10, TLX, TRA2, 10, CD46 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
MEM-258 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
CD46 functions as an inhibitor of complement activation limiting the formation and activity of C3 convertases, CD46 is expressed by all nucleated cells, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The molecule is also expressed by sperm and may be important in the process of fertilization, This particular antibody might cross react with speacies outside of the listed ones, a broadly expressed glycoprotein also known as membrane co-factor protein (MCP), often as multiple isoforms on the same cells, Recognizes the human CD46 cell surface antigen |
| Purification method: |
Protein A Purified |
| Form/Appearance: |
0, Sourced in TCS, 09% sodium azide, PBS |
| Concentration: |
1 miligram per 1 mililiter |
| Storage and shipping: |
For long term storage aliquot and keep the antibody at -20 degrees Celsius, Freeze-thaw cycles should be avoided in order to retain the activity of the antibody, Store at +4 degrees Celsius for short term storage |
| Tested applications:: |
Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Western Blot (WB), Immunohistochemistry (IHC - Paraffin) |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| Gene target: |
Monoclonal [ MEM-258] (IgG1) MCP / CD46 |
| Short name: |
Mouse Monoclonal [clone MEM-258] (IgG1) MCP / CD46 Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype: |
IgG1 |
| Species: |
Humans, Mouses, Human |
| Alternative name: |
complement regulatory protein (Antibody to), sapiens MCP / CD46 molecule, Mouse monoclonal [clonality MEM-258] (IgG1) to H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
AHUS2 and MCP and MIC10 and TLX and TRA2, BT, CD46 and IDBG-106372 and ENSG00000117335 and 4179, Cd46 and IDBG-209330 and ENSMUSG00000016493 and 17221, Cell surfaces, cadherin binding, classical pathway and biological process this GO :0007338 and single fertilization and biological process this GO :0008593 and regulation of Notch signaling pathway and biological process this GO :0009986 and cell surface and cellular component this GO :0010628 and positive regulation of gene expression and biological process this GO :0010629 and negative regulation of gene expression and biological process this GO :0016032 and viral process and biological process this GO :0030449 and regulation of complement activation and biological process this GO :0032613 and interleukin-10 production and biological process this GO :0032733 and positive regulation of interleukin-10 production and biological process this GO :0035581 and sequestering of extracellular ligand from receptor and biological process this GO :0042102 and positive regulation of T cell proliferation and biological process this GO :0043382 and positive regulation of memory T cell differentiation and biological process this GO :0045087 and innate immune response and biological process this GO :0045296 and cadherin binding and molecular function this GO :0045591 and positive regulation of regulatory T cell differentiation and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0071636 and positive regulation of transforming growth factor beta production and biological process, complement regulatory protein, this GO :0002079 and inner acrosomal membrane and cellular component this GO :0002250 and adaptive immune response and biological process this GO :0002456 and T cell mediated immunity and biological process this GO :0004872 and receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006958 and complement activation, this GO :0004872 : receptor activity, this GO :0004872 : receptor activity and also this GO :0005515 : protein binding and also this GO :0045296 : cadherin binding, this GO :0005515 : protein binding, this GO :0045296 : cadherin binding, 10, 68611 and IDBG-638462 and ENSBTAG00000005397 and 280851, CD46 molecule |
| Identity: |
6953 |
| Gene: |
CD46 |
More about : CD46 |
| Long gene name: |
CD46 molecule |
| Synonyms gene: |
MIC10 MCP |
| Synonyms gene name: |
antigen identified by monoclonal antibody TRA-2-10 membrane cofactor protein (CD46, complement regulatory protein , complement regulatory protein CD46 molecule, trophoblast-lymphocyte cross-reactive antigen) CD46 antigen |
| Synonyms: |
TRA2, 10 MGC26544 TLX |
| Locus: |
1q32, 2 |
| Discovery year: |
1988-08-31 |
| GenBank acession: |
BC030594 |
| Entrez gene record: |
4179 |
| Pubmed identfication: |
7929741 |
| RefSeq identity: |
NM_172361 |
| Classification: |
Sushi domain containing Complement system CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000036397 |
| Locus Specific Databases: |
LRG_155 |