| Also known as: |
ITGB2 / MAC-1 / CD18 |
| Other names: |
CD18/11B, CD18/11C, CD_antigen: CD18, Cell surface adhesion glycoproteins LFA-1/CR3/p150, Complement receptor C3 subunit beta, Integrin beta-2, beta 2, beta 2 (complement component 3 receptor 3 and 4 subunit), cell surface adhesion glycoprotein (LFA-1/CR3/P150, complement receptor C3 beta-subunit, integrin, integrin beta chain, integrin beta-2, leukocyte cell adhesion molecule CD18, leukocyte-associated antigens CD18/11A, 95 subunit beta, 959 beta subunit precursor), integrin beta-2 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
ITGB2 |
| Gene name synonims: |
CD18, MAC-1 |
| Other gene names: |
CD18, CD18, ITGB2, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7, MFI7, ITGB2 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
MEM-48 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
CD18 is a 90-95 kD type I transmembrane protein expressed on all leukocytes, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, beta2 integrin), Recognizes an epitope involving residues 534-546 in cysteine-rich repeat 3 of the CD18 antigen (integrin beta2 subunit |
| Purification method: |
Protein A Purified |
| Form/Appearance: |
0, approx, pH 7, 2 um filter sterilized, 4, Phosphate buffered saline (PBS) |
| Concentration: |
1 miligram per 1 mililiter |
| Storage and shipping: |
Do not freeze, Store the antibody ats should be kept in the range of 1-7 degrees Celsius |
| Tested applications:: |
Flow Cytometry (FC/FACS), Functional Assay, IHC - Frozen), Immunoprecipitation (IP), Western Blot (WB), Immunohistochemistry (IHC - Paraffin |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| Gene target: |
Monoclonal [ MEM-48] (IgG1) ITGB2 / MAC-1 / CD18 |
| Short name: |
Mouse Monoclonal [clone MEM-48] (IgG1) ITGB2 / MAC-1 / CD18 Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype: |
IgG1 |
| Species: |
Humans, Mouses, Human |
| Alternative name: |
b 2 (complement component 3 receptor 3 and 4 subunit) / MAC-1 / CD18 (Antibody to), sapiens integrin, Mouse monoclonal [clonality MEM-48] (IgG1) to H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CD18 and LAD and LCAMB and LFA-1 and MAC-1 and MF17 and MFI7, Cell surfaces, ITGB2 and IDBG-5590 and ENSG00000160255 and 3689, ITGB2 and IDBG-639611 and ENSBTAG00000017060 and 281877, beta 2 (complement component 3 receptor 3 and 4 subunit), metal ion binding, this GO :0001948 and glycoprotein binding and molecular function this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0004872 and receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0006915 and apoptotic process and biological process this GO :0006954 and inflammatory response and biological process this GO :0007155 and cell adhesion and biological process this GO :0007159 and leukocyte cell-cell adhesion and biological process this GO :0007160 and cell-matrix adhesion and biological process this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0007267 and cell-cell signaling and biological process this GO :0007275 and multicellular organismal development and biological process this GO :0007596 and blood coagulation and biological process this GO :0008305 and integrin complex and cellular component this GO :0008360 and regulation of cell shape and biological process this GO :0009986 and cell surface and cellular component this GO :0016020 and membrane and cellular component this GO :0019901 and protein kinase binding and molecular function this GO :0030198 and extracellular matrix organization and biological process this GO :0030593 and neutrophil chemotaxis and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0043235 and receptor complex and cellular component this GO :0045087 and innate immune response and biological process this GO :0046872 and metal ion binding and molecular function this GO :0050730 and regulation of peptidyl-tyrosine phosphorylation and biological process this GO :0050776 and regulation of immune response and biological process this GO :0050900 and leukocyte migration and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0001948 : glycoprotein binding, this GO :0001948 : glycoprotein binding and also this GO :0004872 : receptor activity and also this GO :0005515 : protein binding and also this GO :0019901 : protein kinase binding and also this GO :0046872 : metal ion binding, this GO :0004872 : receptor activity, this GO :0005515 : protein binding, this GO :0019901 : protein kinase binding, this GO :0046872 : metal ion binding, integrin |
| Identity: |
6149 |
| Gene: |
ITGAM |
More about : ITGAM |
| Long gene name: |
integrin subunit alpha M |
| Synonyms gene: |
CR3A CD11B |
| Synonyms gene name: |
alpha, alpha M (complement component 3 receptor 3 subunit) , alpha M (complement component receptor 3, also known as CD11b (p170), integrin, macrophage antigen alpha polypeptide) integrin |
| Synonyms: |
MAC-1 CD11b |
| Synonyms name: |
complement component 3 receptor 3 subunit |
| Locus: |
16p11, 2 |
| Discovery year: |
1988-08-05 |
| GenBank acession: |
J03925 |
| Entrez gene record: |
3684 |
| RefSeq identity: |
NM_000632 |
| Classification: |
Complement system Integrin alpha subunits CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000176612 |