| Also known as: |
TNFRSF11A / RANK |
| Other names: |
18, CD_antigen: CD265, NFKB activator, ODFR, Osteoclast differentiation factor receptor, Paget disease of bone 2, Receptor activator of NF-KB, Tumor necrosis factor receptor superfamily member 11A, chromosomal region 1, loss of heterozygosity, member 11a, osteoclast differentiation factor receptor, receptor activator of NF-KB, receptor activator of nuclear factor-kappa B, tumor necrosis factor receptor superfamily, tumor necrosis factor receptor superfamily member 11A, tumor necrosis factor receptor superfamily member 11A isoform 1 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
TNFRSF11A |
| Other gene names: |
CD265, FEO, LOH18CR1, ODFR, ODFR, OFE, OPTB7, OSTS, PDB2, RANK, RANK, TNFRSF11A, TRANCER, TNFRSF11A |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
9A725 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, Mouse (Mus musculus), the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This antibody recognizes an epitope located between amino acid residues 330-427 of human RANK, This particular antibody might cross react with speacies outside of the listed ones, A fusion protein containing amino acid residues 326-616 of human RANK was used as immunogen |
| Purification method: |
Protein G Purified |
| Form/Appearance: |
0, 0, 05% sodium azide, 2% gelatin, PBS |
| Concentration: |
5 mg/ml |
| Storage and shipping: |
For long term storage aliquot and keep the antibody at -20 degrees Celsius, Freeze-thaw cycles should be avoided in order to retain the activity of the antibody, Store at +4 degrees Celsius for short term storage |
| Tested applications:: |
Flow Cytometry (FC/FACS), Western Blot (WB), Immunohistochemistry (IHC - Paraffin) |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| Gene target: |
Monoclonal [ 9A725] (IgG1) TNFRSF11A / RANK |
| Short name: |
Mouse Monoclonal [clone 9A725] (IgG1) TNFRSF11A / RANK Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype: |
IgG1 |
| Species: |
Humans, Mouses, Human |
| Alternative name: |
NFKB activator / RANK (Antibody to), member 11a, sapiens tumor necrosis factor receptor superfamily, Mouse monoclonal [clonality 9A725] (IgG1) to H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CD265 and FEO and LOH18CR1 and ODFR and OFE and OPTB7 and OSTS and PDB2 and RANK and TRANCER, Cell surfaces, NFKB activator, TNFRSF11A and IDBG-4279 and ENSG00000141655 and 8792, TNFRSF11A and IDBG-644974 and ENSBTAG00000007569 and 530884, Tnfrsf11a and IDBG-185529 and ENSMUSG00000026321 and 21934, member 11a, metal ion binding, this GO :0001503 and ossification and biological process this GO :0002250 and adaptive immune response and biological process this GO :0002548 and monocyte chemotaxis and biological process this GO :0004872 and receptor activity and molecular function this GO :0004888 and transmembrane signaling receptor activity and molecular function this GO :0005031 and tumor necrosis factor-activated receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0007165 and signal transduction and biological process this GO :0007267 and cell-cell signaling and biological process this GO :0007275 and multicellular organismal development and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009314 and response to radiation and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0019955 and cytokine binding and molecular function this GO :0030316 and osteoclast differentiation and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0033209 and tumor necrosis factor-mediated signaling pathway and biological process this GO :0034097 and response to cytokine and biological process this GO :0034612 and response to tumor necrosis factor and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043507 and positive regulation of JUN kinase activity and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048535 and lymph node development and biological process this GO :0051091 and positive regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0060086 and circadian temperature homeostasis and biological process this GO :0060749 and mammary gland alveolus development and biological process this GO :0070555 and response to interleukin-1 and biological process this GO :0071812 and positive regulation of fever generation by positive regulation of prostaglandin secretion and biological process this GO :0071847 and TNFSF11-mediated signaling pathway and biological process this GO :0071848 and positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling and biological process, this GO :0004872 : receptor activity, this GO :0004872 : receptor activity and also this GO :0004888 : transmembrane signaling receptor activity and also this GO :0005031 : tumor necrosis factor-activated receptor activity and also this GO :0005515 : protein binding and also this GO :0019955 : cytokine binding and also this GO :0046872 : metal ion binding, this GO :0004888 : transmembrane signaling receptor activity, this GO :0005031 : tumor necrosis factor-activated receptor activity, this GO :0005515 : protein binding, this GO :0019955 : cytokine binding, this GO :0046872 : metal ion binding, tumor necrosis factor receptor superfamily |
| Identity: |
11908 |
| Gene: |
TNFRSF11A |
More about : TNFRSF11A |
| Long gene name: |
TNF receptor superfamily member 11a |
| Synonyms gene: |
PDB2 LOH18CR1 |
| Synonyms gene name: |
18, NFKB activator , activator of NFKB Paget disease of bone 2 loss of heterozygosity, chromosomal region 1 tumor necrosis factor receptor superfamily, member 11a, member 11a, tumor necrosis factor receptor superfamily |
| Synonyms: |
RANK CD265 FEO |
| Locus: |
18q21, 33 |
| Discovery year: |
1998-12-04 |
| GenBank acession: |
AF018253 |
| Entrez gene record: |
8792 |
| Pubmed identfication: |
9367155 10615125 |
| Classification: |
CD molecules Tumor necrosis factor receptor superfamily |
| Havana BLAST/BLAT: |
OTTHUMG00000132779 |
| Locus Specific Databases: |
LRG_194 |