| Also known as: |
PMS2 |
| Other names: |
DNA mismatch repair protein PMS2, DNA mismatch repair protein PMS2, H_DJ0042M02, Mismatch repair endonuclease PMS2, PMS1 protein homolog 2, PMS1 protein homolog 2, PMS2 postmeiotic segregation increased 2 (S, cerevisiae), mismatch repair endonuclease PMS2, 9, mismatch repair endonuclease PMS2 isoform a |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
PMS2 |
| Other gene names: |
HNPCC4, PMS2, PMS2CL, PMSL2, PMSL2, PMS2 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
163C1251 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, Gorilla, Human (Homo sapiens), the reactivity of the antibody may extend to other species which are not listed hereby, Gibbon |
| Specificity and cross-reactivity: |
GenBank No, NP_000526, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, 1, A synthetic peptide corresponding to amino acids 623-639 SSLAKRIKQLHHEAQQS of human PMS2 |
| Purification method: |
Protein G Purified |
| Form/Appearance: |
0, 02% sodium azide, PBS |
| Concentration: |
5 mg/ml |
| Storage and shipping: |
For long term storage aliquot and keep the antibody at -20 degrees Celsius, Freeze-thaw cycles should be avoided in order to retain the activity of the antibody, Store at +4 degrees Celsius for short term storage |
| Tested applications:: |
Western Blot (WB), Immunohistochemistry (IHC - Paraffin) |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| Gene target: |
Monoclonal [ 163C1251] (IgG1) PMS2 |
| Short name: |
Mouse Monoclonal [clone 163C1251] (IgG1) PMS2 Antibody |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype: |
IgG1 |
| Species: |
Humans, Mouses, Human |
| Alternative name: |
cerevisiae) (Antibody to), sapiens PMS2 postmeiotic segregation increased 2 (S, Mouse monoclonal [clonality 163C1251] (IgG1) to H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
HNPCC4 and PMS2CL and PMSL2, MutSalpha complex binding, PMS2 and IDBG-640975 and ENSBTAG00000007364 and 527039, PMS2 and IDBG-7921 and ENSG00000122512 and 5395, Pms2 and IDBG-259679 and ENSMUSG00000079109 and 18861, cerevisiae), nuclei, this GO :0003677 and DNA binding and molecular function this GO :0003697 and single-stranded DNA binding and molecular function this GO :0004519 and endonuclease activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006200 and ATP catabolic process and biological process this GO :0006281 and DNA repair and biological process this GO :0006298 and mismatch repair and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0015630 and microtubule cytoskeleton and cellular component this GO :0016446 and somatic hypermutation of immunoglobulin genes and biological process this GO :0016447 and somatic recombination of immunoglobulin gene segments and biological process this GO :0016887 and ATPase activity and molecular function this GO :0030983 and mismatched DNA binding and molecular function this GO :0032138 and single base insertion or deletion binding and molecular function this GO :0032300 and mismatch repair complex and cellular component this GO :0032389 and MutLalpha complex and cellular component this GO :0032407 and MutSalpha complex binding and molecular function this GO :0042493 and response to drug and biological process this GO :0090305 and nucleic acid phosphodiester bond hydrolysis and biological process, this GO :0003677 : DNA binding, this GO :0003677 : DNA binding and also this GO :0003697 : single-stranded DNA binding and also this GO :0004519 : endonuclease activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0016887 : ATPase activity and also this GO :0030983 : mismatched DNA binding and also this GO :0032138 : single base insertion or deletion binding and also this GO :0032407 : MutSalpha complex binding, this GO :0003697 : single-stranded DNA binding, this GO :0004519 : endonuclease activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0016887 : ATPase activity, this GO :0030983 : mismatched DNA binding, this GO :0032138 : single base insertion or deletion binding, this GO :0032407 : MutSalpha complex binding, PMS2 postmeiotic segregation increased 2 (S |
| Identity: |
9122 |
| Gene: |
PMS2 |
More about : PMS2 |
| Long gene name: |
PMS1 homolog 2, mismatch repair system component |
| Synonyms gene: |
PMSL2 |
| Synonyms gene name: |
cerevisiae) 2 PMS2 postmeiotic segregation increased 2 (S, cerevisiae) PMS1 homolog 2, mismatch repair protein , postmeiotic segregation increased (S |
| Synonyms: |
H_DJ0042M02, 9 HNPCC4 MLH4 |
| Locus: |
7p22, 1 |
| Discovery year: |
1994-12-13 |
| Entrez gene record: |
5395 |
| Pubmed identfication: |
8072530 |
| RefSeq identity: |
NM_000535 |
| Classification: |
MutL homologs |
| Havana BLAST/BLAT: |
OTTHUMG00000023135 |
| Locus Specific Databases: |
HNPCC Colon cancer gene variant databases PMS2 database at LOVD-China LRG_161 , Hereditary Non-Polyposis Colorectal Cancer |