| Also known as: |
MCL1 / MCL 1 |
| Other names: |
Bcl-2-like protein 3, Bcl-2-related protein EAT/mcl1, Bcl2-L-3, Induced myeloid leukemia cell differentiation protein Mcl-1, bcl-2-like protein 3, bcl-2-related protein EAT/mcl1, induced myeloid leukemia cell differentiation protein Mcl-1, mcl1/EAT, myeloid cell leukemia 1, myeloid cell leukemia ES, myeloid cell leukemia sequence 1 (BCL2-related), induced myeloid leukemia cell differentiation protein Mcl-1 isoform 1 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
MCL1 |
| Gene name synonims: |
MCL 1 |
| Other gene names: |
BCL2L3, BCL2L3, Bcl2-L-3, EAT, MCL1, MCL1-ES, MCL1L, MCL1S, Mcl-1, TM, bcl2-L-3, mcl1/EAT, MCL1 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
8C6D4B1, 8C6 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, Ni-NTA purified recombinant protein MCL-1expressed in E Coli strain M15 |
| Purification method: |
Protein G Purified |
| Form/Appearance: |
0, pH 7, 03% sodium azide, 4, PBS |
| Concentration: |
1 miligram per 1 mililiter |
| Storage and shipping: |
Cycles of freezing and defrosting may denaturate the polypeptide chains of the antibodies and reduce their activity, For longer storage the antibody should be kept at -20 degrees Celsius, For short term storage keep the antibody at +4 degrees Celsius |
| Tested applications:: |
ELISA (EIA), IHC - Frozen), Western Blot (WB), Immunohistochemistry (IHC - Paraffin |
| Properties: |
Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About: |
Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test: |
A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name: |
Mus musculus |
| Gene target: |
8C6D4B1] (IgG1) MCL1 / MCL 1, Monoclonal [ 8C6 |
| Short name: |
8C6D4B1] (IgG1) MCL1 / MCL 1 Antibody, Mouse Monoclonal [clone 8C6 |
| Technique: |
Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype: |
IgG1 |
| Species: |
Humans, Mouses, Human |
| Alternative name: |
8C6D4B1] (IgG1) to H, sapiens myeloid cell leukemia sequence 1 (BCL2-related) / MCL 1 (Antibody to), Mouse monoclonal [clonality 8C6 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BH3 domain binding, MCL1 and IDBG-102145 and ENSG00000143384 and 4170, Mcl1 and IDBG-173221 and ENSMUSG00000038612 and 17210, bcl2-L-3 and BCL2L3 and EAT and Mcl-1 and MCL1-ES and mcl1/EAT and MCL1L and MCL1S and TM, nuclei, this GO :0001709 and cell fate determination and biological process this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005759 and mitochondrial matrix and cellular component this GO :0005829 and cytosol and cellular component this GO :0007275 and multicellular organismal development and biological process this GO :0008630 and intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :0008637 and apoptotic mitochondrial changes and biological process this GO :0015266 and protein channel activity and molecular function this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0019725 and cellular homeostasis and biological process this GO :0034097 and response to cytokine and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0051434 and BH3 domain binding and molecular function this GO :0071806 and protein transmembrane transport and biological process this GO :0097136 and Bcl-2 family protein complex and cellular component this GO :0097192 and extrinsic apoptotic signaling pathway in absence of ligand and biological process this GO :0097194 and execution phase of apoptosis and biological process this GO :1900118 and negative regulation of execution phase of apoptosis and biological process this GO :2000811 and negative regulation of anoikis and biological process this GO :2001020 and regulation of response to DNA damage stimulus and biological process this GO :2001240 and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process this GO :2001243 and negative regulation of intrinsic apoptotic signaling pathway and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0015266 : protein channel activity and also this GO :0042803 : protein homodimerization activity and also this GO :0046982 : protein heterodimerization activity and also this GO :0051434 : BH3 domain binding, this GO :0015266 : protein channel activity, this GO :0042803 : protein homodimerization activity, this GO :0046982 : protein heterodimerization activity, this GO :0051434 : BH3 domain binding, myeloid cell leukemia sequence 1 (BCL2-related) |
| Identity: |
6943 |
| Gene: |
MCL1 |
More about : MCL1 |
| Long gene name: |
BCL2 family apoptosis regulator |
| Synonyms gene name: |
myeloid cell leukemia sequence 1 (BCL2-related) myeloid cell leukemia 1 |
| Synonyms: |
BCL2L3 Mcl-1 |
| Locus: |
1q21, 2 |
| Discovery year: |
1993-11-09 |
| GenBank acession: |
BC017197 |
| Entrez gene record: |
4170 |
| Pubmed identfication: |
7682708 7835896 |
| RefSeq identity: |
NM_021960 |
| Classification: |
BCL2 family |
| Havana BLAST/BLAT: |
OTTHUMG00000034867 |