| Also known as: |
HIF1 ALPHA |
| Other names: |
ARNT interacting protein, ARNT-interacting protein, ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, Class E basic helix-loop-helix protein 78, HIF-1-alpha, Hypoxia-inducible factor 1-alpha, Member of PAS protein 1, PAS domain-containing protein 8, PAS domain-containing protein 8, alpha subunit (basic helix-loop-helix transcription factor), alpha subunit (basic helix-loop-helix transcription factor), bHLHe78, basic-helix-loop-helix-PAS protein MOP1, class E basic helix-loop-helix protein 78, hypoxia inducible factor 1, hypoxia-inducible factor 1, hypoxia-inducible factor 1 alpha isoform I, hypoxia-inducible factor 1-alpha, hypoxia-inducible factor1alpha, member of PAS protein 1, member of PAS superfamily 1, 3, hypoxia-inducible factor 1-alpha isoform 3 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
HIF1 ALPHA |
| Other gene names: |
BHLHE78, HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, HIF1-alpha, HIF1A, MOP1, MOP1, PASD8, PASD8, bHLHe78, bHLHe78, HIF1A |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
ESEE122 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Clone ESEE122 has been shown to be suitable for the staining of snap-frozen cell pellets, During hypoxic conditions, HIF1A accumulates in the nucleus and activates the transcription of many genes encoding proteins involved in the production of oxygen delivery and metabolic adaptation, HIF1A and HIF1B (HIF1 beta/ARNT) form the highly-conserved heterodimeric HIF-1 transcriptional complex, HIF1A is targeted by HIF prolyl-hydroxylase, Overexpression of HIF1A occurs in many common human cancers, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, Under normal oxygen conditions, a widely expressed bHLH-PAS transcription factor, bladder and renal carcinomas, followed by rapid protease degradation, including pancreatic, otherwise known as Hypoxia-inducible factor 1-alpha, such as vascular endothelial growth factor (VEGF) and glucose transporters, which acts as a critical regulatory protein in the host response to oxygen depravation (hypoxia), which is inhibited during hypoxia, HIF1 ALPHA This item specifically recognizes human HIF1 alpha (HIF1A) |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from the date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
ELISA (EIA), Western Blot (WB), Immunohistology - Paraffin (IHC) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
HIF1 ALPHA |
| Short name: |
MOUSE Anti-HUMAN HIF1 ALPHA Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens HIF1 a (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Identity: |
4910 |
| Gene: |
HIF1A |
More about : HIF1A |
| Long gene name: |
hypoxia inducible factor 1 alpha subunit |
| Synonyms gene name: |
alpha subunit (basic helix-loop-helix transcription factor) , hypoxia inducible factor 1 |
| Synonyms: |
MOP1 HIF-1alpha PASD8 HIF1 bHLHe78 |
| Locus: |
14q23, 2 |
| Discovery year: |
1995-03-27 |
| GenBank acession: |
U22431 |
| Entrez gene record: |
3091 |
| Pubmed identfication: |
8786149 9079689 |
| RefSeq identity: |
NM_001530 |
| Classification: |
Basic helix-loop-helix proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000140344 |