| Also known as: |
CD254 |
| Other names: |
ODF, OPG ligand, OPGL, Osteoclast differentiation factor, Osteoprotegerin ligand, RANKL, Receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine, TNF-related activation-induced cytokine, Tumor necrosis factor ligand superfamily member 11, member 11, osteoclast differentiation factor, osteoprotegerin ligand, receptor activator of NF-kappaB ligand, receptor activator of nuclear factor kappa B ligand, receptor activator of nuclear factor kappa-B ligand, tumor necrosis factor (ligand) superfamily, tumor necrosis factor ligand superfamily member 11, tumor necrosis factor-related activation-induced cytokine, tumor necrosis factor ligand superfamily member 11 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD254 |
| Other gene names: |
Ly109l, ODF, ODF, OPG, OPGL, OPGL, Opgl, RANKL, RANKL, Rankl, TRANCE, Tnfsf11, Trance, Trance, Tnfsf11 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2a |
| Clone: |
IK22/5 |
| Host organism: |
Rat (Rattus norvegicus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus) |
| Specificity and cross-reactivity: |
CD254 is a cytokine that binds osteoprotegerin or RANK and plays an important role in bone metabolism, It may play a role in regulating interactions between T cells and dendritic cells and in the regulation of T cell-dependent immune responses, Overproduction of CD254 is implicated in a range of degenerative bone diseases, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_Clone IK22/5 blocks ligand binding, _x000D__x000D_It is also expressed by T helper cells and augments the ability of dendritic cells to stimulate naï, a member of the tumour necrosis factor ligand superfamily, otherwise known as Receptor activator of nuclear factor kappa B ligand (RANKL) or TNF-related activation-induced cytokine (TRANCE), where it acts as an osteoclast differentiation and activation factor, CD254 This item recognises CD254, ve T cell proliferation |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
IgG concentration 500ug/1000ul |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistology - Frozen (IHC), Western Blot (WB), Immunoprecipitation (IP) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD254 |
| Short name: |
RAT ANTI MOUSE CD254 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
RAT antibody to MOUSE CD254 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11926 |
| Gene: |
TNFSF11 |
More about : TNFSF11 |
| Long gene name: |
tumor necrosis factor superfamily member 11 |
| Synonyms gene name: |
member 11 , tumor necrosis factor (ligand) superfamily |
| Synonyms: |
TRANCE RANKL OPGL ODF CD254 |
| Locus: |
13q14 |
| Discovery year: |
1998-12-04 |
| GenBank acession: |
AF013171 |
| Pubmed identfication: |
9312132 9367155 |
| Classification: |
Tumor necrosis factor superfamily CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000016807 |