| Long name: |
Biotin Conjugated, BCL-2 (1A5) Monoclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
BCL-2 |
| Specificity: |
This is a highly specific antibody against BCL-2 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Monoclonal |
| Clone: |
1A5 |
| Concentration: |
1ug per 1ul |
| Source: |
Recombinant protein fragment (1-220 amino acids range) of human Bcl-2 |
| Gene ID number: |
596 |
| Swiss Prot: |
P10415 |
| Tested applications: |
WB |
| Recommended dilutions: |
WB(1:100-1000) |
| Crossreactivity: |
Mouse, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Appears to function in a feedback loop system with caspases, Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1), May attenuate inflammation by impairing NLRP1-inflammasome activation, Regulates cell death by controlling the mitochondrial membrane permeability, hence CASP1 activation and IL1B release, Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells |
| Purification method: |
Purified by Protein G |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
Bcl-2 PPP1R50 |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
BCL-2 (1A5) Conjugated |
| Short name: |
Conjugated, BCL-2 (1A5) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, BCL-2 (1A5) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
990 |
| Gene: |
BCL2 |
More about : BCL2 |
| Long gene name: |
BCL2, apoptosis regulator |
| Synonyms gene name: |
B-cell CLL/lymphoma 2 |
| Synonyms name: |
protein phosphatase 1, regulatory subunit 50 |
| Locus: |
18q21, 33 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
M14745 |
| Entrez gene record: |
596 |
| RefSeq identity: |
NM_000633 NM_000657 |
| Classification: |
Protein phosphatase 1 regulatory subunits BCL2 family |
| Havana BLAST/BLAT: |
OTTHUMG00000132791 |
| Locus Specific Databases: |
LRG_1113 |