| Also known as: |
GITRL |
| Other names: |
AITR ligand, AITRL, Activation-inducible TNF-related ligand, GITR ligand, Glucocorticoid-induced TNF-related ligand, Tumor necrosis factor ligand superfamily member 18, activation-inducible TNF-related ligand, glucocorticoid-induced TNF-related ligand, glucocorticoid-induced TNFR-related protein ligand, member 18, tumor necrosis factor (ligand) superfamily, tumor necrosis factor ligand superfamily member 18, tumor necrosis factor ligand superfamily member 18 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
GITRL |
| Other gene names: |
AITRL, AITRL, AITRL, GITRL, GITRL, TL6, TL6, TNFSF18, hGITRL, hGITRL, TNFSF18 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
YGL386 |
| Host organism: |
Rat (Rattus norvegicus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Mouse (Mus musculus) |
| Specificity and cross-reactivity: |
Expression of mouse GITRL can be transiently up regulated on these cells, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_Mouse GITRL is predominantly expressed on immature and mature dendritic cells, _x000D__x000D_Studies demonstrate that GITRL can neutralise the suppressive effects of CD4+CD25+ regulatory T cells and can also provide a co-stimulatory signal for both naï, a 20 kD member of the tumour necrosis factor ligand superfamily, but protein expression is rapidly down modulated shortly after stimulation, following lipolysaccharide (LPS) stimulation, macrophages and B cells, otherwise known as TNSF18, suggesting a key role for GITRL in the regulation of T cell-mediated immunity, GITRL Recognises mouse glucocorticoid-induced tumour necrosis factor receptor ligand (GITRL), ve and primed T cells |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0 mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, Storage in frost-free freezers is not recommended, the antibody should be stored undiluted, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
ELISA (EIA), Flow Cytometry (FACS) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
GITRL |
| Short name: |
RAT ANTI MOUSE GITRL Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
RAT antibody to MOUSE GITRL (Antibody to) |
| Alternative technique: |
antibodies |