| Also known as: |
LOX-1 |
| Other names: |
C-type lectin domain family 8 member A, C-type lectin domain family 8 member A, LOX-1, Lectin-like oxLDL receptor 1, Lectin-like oxidized LDL receptor 1, Lectin-type oxidized LDL receptor 1, Oxidized low-density lipoprotein receptor 1, hLOX-1, hLOX-1, lectin-type oxidized LDL receptor 1, member 1, ox LDL receptor 1, oxidized low density lipoprotein (lectin-like) receptor 1, oxidized low-density lipoprotein receptor 1, oxidized low-density lipoprotein receptor 1, scavenger receptor class E, soluble form, oxidized low-density lipoprotein receptor 1 isoform 2 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
LOX-1 |
| Other gene names: |
CLEC8A, CLEC8A, LOX-1, LOX1, LOX1, LOXIN, Lectin-like oxLDL receptor 1, OLR1, Ox-LDL receptor 1, SCARE1, SLOX1, hLOX-1, OLR1 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
LOX19-22 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
It can be cleaved by an unknown protease at the extracellular juxtamembrane region to release the soluble form (aa58-273) of LOX-1, It is a Type II membrane protein with a typical C-type lectin structure at the extracellular C-terminus which recognises the ligand, LOX-1 activation by oxidised LDL causes endothelial changes such as decreased nitric oxide release and an increased expression of adhesion molecules, LOX-1 also binds activated platelets and apoptotic cells, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The expression of LOX-1 is induced by proatherogenic conditions such as hyperlipidemia, This particular antibody might cross react with speacies outside of the listed ones, This receptor mediates the recognition, a 31kDa protein of the C-type lectin superfamily, hypertension and diabetes and as such appears to contribute to the pathogenesis of vascular disorders, internalisation and degradation of oxidised LDL, particularly atherosclerosis, recognised by This item, LOX-1 This item recognises the lectin-like oxidised low-density lipoprotein (LDL) receptor (LOX-1) |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Western Blot (WB), ELISA (EIA) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
LOX-1 (SOLUBLE) |
| Short name: |
MOUSE Anti-HUMAN LOX-1 (SOLUBLE) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens LOX-1 (SOLUBLE) (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Identity: |
8133 |
| Gene: |
OLR1 |
More about : OLR1 |
| Long gene name: |
oxidized low density lipoprotein receptor 1 |
| Synonyms gene name: |
oxidised low density lipoprotein (lectin-like) receptor 1 |
| Synonyms: |
LOX-1 SCARE1 CLEC8A |
| Locus: |
12p13, 2 |
| Discovery year: |
1998-01-16 |
| GenBank acession: |
D89050 |
| Entrez gene record: |
4973 |
| Pubmed identfication: |
9763655 |
| RefSeq identity: |
NM_002543 |
| Classification: |
Scavenger receptors C-type lectin domain family |
| Havana BLAST/BLAT: |
OTTHUMG00000168527 |